| Gene Symbol |
ST8SIA4
|
| Entrez Gene |
7903
|
| Alt Symbol |
PST, PST1, SIAT8D, ST8SIA-IV
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
|
| Other Description |
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyl transferase|CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase|SIAT8-D|ST8SiaIV|alpha-2,8-sialyltransferase 8D|polysialyltransferase-1|sialyltransferase 8 (alpha-2, 8-polysialytransferase) D|sialyltransferase 8D|sialyltransferase St8Sia IV|sialytransferase St8Sia IV
|
| Swissprots |
Q92693 Q92187 A8KA07 Q8N1F4 G3V104
|
| Accessions |
CAN37586 CAS91698 EAW49104 EAW49105 Q92187 AA836260 AK292872 BAF85561 BC027866 AAH27866 BC040671 BC053657 AAH53657 BI858673 BM921020 DA862968 HQ448744 ADQ33222 L41680 AAC41775 XM_005272078 XP_005272135 XM_011543630 XP_011541932 NM_005668 NP_005659 NM_175052 NP_778222
|
| Function |
Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA), which is present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural cells.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Highly expressed in fetal brain, lung and kidney and in adult heart, spleen and thymus. Present to a lesser extent in adult brain, placenta, lung, large and small intestine and peripheral blood leukocytes.
|