Gene Symbol | ST8SIA4 |
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Entrez Gene | 7903 |
Alt Symbol | PST, PST1, SIAT8D, ST8SIA-IV |
Species | Human |
Gene Type | protein-coding |
Description | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 |
Other Description | CMP-N-acetylneuraminate-poly-alpha-2,8-sialyl transferase|CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase|SIAT8-D|ST8SiaIV|alpha-2,8-sialyltransferase 8D|polysialyltransferase-1|sialyltransferase 8 (alpha-2, 8-polysialytransferase) D|sialyltransferase 8D|sialyltransferase St8Sia IV|sialytransferase St8Sia IV |
Swissprots | Q92693 Q92187 A8KA07 Q8N1F4 G3V104 |
Accessions | CAN37586 CAS91698 EAW49104 EAW49105 Q92187 AA836260 AK292872 BAF85561 BC027866 AAH27866 BC040671 BC053657 AAH53657 BI858673 BM921020 DA862968 HQ448744 ADQ33222 L41680 AAC41775 XM_005272078 XP_005272135 XM_011543630 XP_011541932 NM_005668 NP_005659 NM_175052 NP_778222 |
Function | Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA), which is present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural cells. |
Subcellular Location | Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. |
Tissue Specificity | Highly expressed in fetal brain, lung and kidney and in adult heart, spleen and thymus. Present to a lesser extent in adult brain, placenta, lung, large and small intestine and peripheral blood leukocytes. |
ST8Sia IV CRISPR/Cas9 KO Plasmid (h) - sc-407527 from Santa Cruz Biotechnology
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ST8Sia IV HDR Plasmid (h) - sc-407527-HDR from Santa Cruz Biotechnology
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ST8Sia IV Double Nickase Plasmid (h) - sc-407527-NIC from Santa Cruz Biotechnology
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ST8Sia IV Double Nickase Plasmid (h2) - sc-407527-NIC-2 from Santa Cruz Biotechnology
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ST8Sia IV CRISPR Activation Plasmid (h) - sc-407527-ACT from Santa Cruz Biotechnology
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ST8Sia IV CRISPR Activation Plasmid (h2) - sc-407527-ACT-2 from Santa Cruz Biotechnology
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ST8Sia IV Lentiviral Activation Particles (h) - sc-407527-LAC from Santa Cruz Biotechnology
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ST8Sia IV Lentiviral Activation Particles (h2) - sc-407527-LAC-2 from Santa Cruz Biotechnology
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ST8Sia IV siRNA (h) - sc-92058 from Santa Cruz Biotechnology
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ST8Sia IV shRNA Plasmid (h) - sc-92058-SH from Santa Cruz Biotechnology
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ST8Sia IV shRNA (h) Lentiviral Particles - sc-92058-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU056521 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20677 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20677 from Sigma-Aldrich
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ST8SIA4 siRNA (Human) - CRH5309 from Cohesion Biosciences
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ST8SIA4 - MBS8230558 from MyBioSource
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shRNA set against Human ST8SIA4 (NM_175052.1) - SHH419040 from Creative biogene
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shRNA set against Human ST8SIA4(NM_175052.1) - SHL039086 from Creative biogene
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ST8SIA4 shRNA Plasmid (Human) - CHH5309 from Cohesion Biosciences
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ST8SIA4 miRNA 3'UTR clone - MiUTR1H-09961 from Creative biogene
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ST8SIA4 miRNA 3'UTR clone - MiUTR4H-TG08579 from Creative biogene
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