| Gene Symbol |
GLS2
|
| Entrez Gene |
27165
|
| Alt Symbol |
GA, GLS, LGA, hLGA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glutaminase 2 (liver, mitochondrial)
|
| Other Description |
L-glutamine amidohydrolase|breast cell glutaminase|glutaminase I|glutaminase liver isoform, mitochondrial|phosphate-activated glutaminase|phosphate-dependent glutaminase
|
| Swissprots |
B7Z8Q9 Q9NYY2 Q9UI31 Q8IX91 Q9UI32
|
| Accessions |
AAO13298 CCO13737 EAW96942 EAW96943 EAW96944 EAW96945 Q9UI32 AF038170 AF110329 AF110330 AAF21933 AF110331 AAF21934 AF223944 AAF33826 AF279698 AAG17701 AI241400 AK000467 AK289471 BAF82160 AK294822 BAG57935 AK303772 BAH14045 BC025661 BC036929 BC048344 BC059370 BC119767 AAI19768 BC119768 AAI19769 BC166649 AAI66649 BI916699 DA060302 DA180204 HM775422 ADR77821 HM775423 ADR77822 HM775424 ADR77823 XM_005268797 XP_005268854 NM_001280796 NP_001267725 NM_001280797 NP_001267726 NM_001280798 NP_001267727 NM_013267 NP_037399 NM_138566
|
| Function |
Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation. {ECO:0000269|PubMed:20378837}.
|
| Subcellular Location |
Mitochondrion {ECO:0000269|PubMed:20378837}.
|
| Tissue Specificity |
Highly expressed in liver. Expressed in brain and pancreas. Not observed in heart, placenta, lung, skeletal muscle and kidney. Expression is significantly reduced in hepatocellular carcinomas. {ECO:0000269|PubMed:10620514, ECO:0000269|PubMed:20378837}.
|
| Top Pathways |
Central carbon metabolism in cancer, MicroRNAs in cancer, Glutamatergic synapse, GABAergic synapse, Proximal tubule bicarbonate reclamation
|