GLS2

Gene Symbol GLS2
Entrez Gene 27165
Alt Symbol GA, GLS, LGA, hLGA
Species Human
Gene Type protein-coding
Description glutaminase 2 (liver, mitochondrial)
Other Description L-glutamine amidohydrolase|breast cell glutaminase|glutaminase I|glutaminase liver isoform, mitochondrial|phosphate-activated glutaminase|phosphate-dependent glutaminase
Swissprots B7Z8Q9 Q9NYY2 Q9UI31 Q8IX91 Q9UI32
Accessions AAO13298 CCO13737 EAW96942 EAW96943 EAW96944 EAW96945 Q9UI32 AF038170 AF110329 AF110330 AAF21933 AF110331 AAF21934 AF223944 AAF33826 AF279698 AAG17701 AI241400 AK000467 AK289471 BAF82160 AK294822 BAG57935 AK303772 BAH14045 BC025661 BC036929 BC048344 BC059370 BC119767 AAI19768 BC119768 AAI19769 BC166649 AAI66649 BI916699 DA060302 DA180204 HM775422 ADR77821 HM775423 ADR77822 HM775424 ADR77823 XM_005268797 XP_005268854 NM_001280796 NP_001267725 NM_001280797 NP_001267726 NM_001280798 NP_001267727 NM_013267 NP_037399 NM_138566
Function Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation. {ECO:0000269|PubMed:20378837}.
Subcellular Location Mitochondrion {ECO:0000269|PubMed:20378837}.
Tissue Specificity Highly expressed in liver. Expressed in brain and pancreas. Not observed in heart, placenta, lung, skeletal muscle and kidney. Expression is significantly reduced in hepatocellular carcinomas. {ECO:0000269|PubMed:10620514, ECO:0000269|PubMed:20378837}.
Top Pathways Central carbon metabolism in cancer, MicroRNAs in cancer, Glutamatergic synapse, GABAergic synapse, Proximal tubule bicarbonate reclamation

LGA (E-15) - sc-168423 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

LGA (T-12) - sc-168424 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
LGA (T-12): sc-168424. Western blot analysis of LGA expression in IMR-32 whole cell lysate.

Anti-GLS2 antibody - ab113509 from Abcam

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Ab113509 IHC-FoFr on rat brain tissue sections. The antibody was used at 1/1000 in the free floating technique for 18 hours at 20°C. There was no blocking step.See Abreview

Anti-GLS2 antibody - ab150474 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-GLS2 antibody (ab150474) at 1 µg/ml + Liver (Mouse) Tissue Lysate at 10 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-GLS2 / Glutaminase 2 Antibody (aa505-532, AP) - LS-C259528 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GLS2 / Glutaminase 2 Antibody (aa505-532, APC) - LS-C259529 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GLS2 / Glutaminase 2 Antibody (aa505-532, Biotin) - LS-C259530 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GLS2 / Glutaminase 2 Antibody (aa505-532, FITC) - LS-C259531 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GLS2 / Glutaminase 2 Antibody (aa505-532, Azide-free, HRP) - LS-C259532 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GLS2 / Glutaminase 2 Antibody (aa505-532, PE) - LS-C259534 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GLS2 / Glutaminase 2 Antibody (aa505-532) - LS-C321658 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GLS2 / Glutaminase 2 Antibody (aa241-290) - LS-C80586 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
GLS2 / Glutaminase 2 antibody LS-C80586 was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.

Anti-GLS2 / Glutaminase 2 Antibody (Internal) - LS-C144338 from LifeSpan Bioscience

Prices $345.00, $1,035.00
Sizes 100 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of GLS2 in Human Kidney cells with GLS2 antibody at 20 ug/ml.

Anti-GLS / Glutaminase Antibody (aa516-545) - LS-C166517 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
GLS Antibody IHC of formalin-fixed and paraffin-embedded mouse brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-GLS2 / Glutaminase 2 Antibody (aa498-524) - LS-C166518 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
GLS2 antibody(C-term E513) immunohistochemistry of formalin-fixed and paraffin-embedded human hepatocarcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.

GLS2 Antibody - NBP1-76544 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

GLS2 Antibody - NBP1-54773 from Novus Biologicals

Prices $299.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: GLS2 Antibody [NBP1-54773] - Sample Tissue: Human NCI-H226 Antibody Dilution: 1.0 ug/ml

GLS2 Antibody - NBP1-81856 from Novus Biologicals

Host Rabbit
Clonality Polyclonal
Western Blot: GLS2 Antibody [NBP1-81856] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells). Lane 2: NBT-II cell lysate (Rat Wistar bladder tumour cells).

GLS2 Polyclonal Antibody - bs-13376R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded rat brain labeled with Anti-GLS2/LGA Polyclonal Antibody, Unconjugated (bs-13376R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Rabbit Anti-GLS2 Polyclonal Antibody - bs-4688R from Bioss

Prices $245.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded rat liver labeled with Rabbit Anti Glutaminase Polyclonal Antibody, Unconjugated (bs-4688R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

GLS2 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-13376R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GLS2 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-13376R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GLS2 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-13376R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GLS2 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-13376R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GLS2 Polyclonal Antibody, Cy3 Conjugated - bs-13376R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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