Gene Symbol | SLC25A33 |
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Entrez Gene | 84275 |
Alt Symbol | BMSC-MCP, PNC1 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 25 (pyrimidine nucleotide carrier), member 33 |
Other Description | PNC1 protein|bone marrow stromal cell mitochondrial carrier protein|huBMSC-MCP|mitochondrial carrier protein|novel mitochondrial carrier protein|solute carrier family 25 member 33|solute carrier family 25, member 33 |
Swissprots | Q9BSK2 |
Accessions | EAW71620 Q9BSK2 AF495714 AAM18051 AJ880283 CAI54244 BC004991 AAH04991 BC073135 AAH73135 XM_005263503 XP_005263560 XM_011542296 XP_011540598 NM_032315 NP_115691 |
Function | Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria (PubMed:25320081). Transports preferentially uracil, thymine, and cytosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism (PubMed:25320081). Also transports guanine but not adenine (deoxy)nucleotides (PubMed:25320081). Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10- phenanthroline, tannic acid, and mercurials (mercury dichloride, mersalyl acid, p-hydroxymercuribenzoate) (PubMed:25320081). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration (PubMed:20453889). Upon INS or IGF1 stimulation regulates cell growth and proliferation by controlling mitochondrial DNA replication and transcription, the ratio of mitochondria-to nuclear-encoded components of the electron transport chain resulting in control of mitochondrial ROS production (PubMed:20453889, PubMed:17596519). Participates in d |
Subcellular Location | Mitochondrion inner membrane {ECO:0000305|PubMed:14715278}; Multi-pass membrane protein {ECO:0000255}. |
Tissue Specificity | Expressed in the central nervous system. Also expressed in testis and skeletal muscle. Weakly expressed in heart, liver, kidney, prostate, colon and peripheral blood leukocytes. {ECO:0000269|PubMed:14715278}. |
SLC25A33 (H-44) - sc-368727 from Santa Cruz Biotechnology
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SLC25A33 (P-12) - sc-162209 from Santa Cruz Biotechnology
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Anti-SLC25A33 Antibody (aa146-195) - LS-C145648 from LifeSpan Bioscience
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Anti-SLC25A33 Antibody (aa114-321) - LS-C185836 from LifeSpan Bioscience
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SLC25A33 Antibody - NBP1-32499 from Novus Biologicals
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SLC25A33 Antibody - NBP2-13323 from Novus Biologicals
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Anti-SLC25A33 (1-14) antibody produced in rabbit - SAB1103133 from Sigma-Aldrich
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Anti-SLC25A33 antibody produced in rabbit - HPA049982 from Sigma-Aldrich
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Anti-SLC25A33 antibody produced in rabbit - SAB2107541 from Sigma-Aldrich
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Anti-SLC25A33 antibody produced in rabbit - SAB2700337 from Sigma-Aldrich
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SLC25A33 antibody - middle region (ARP60511_P050) - ARP60511_P050 from Aviva Systems Biology
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SLC25A33 antibody - 70R-13036 from Fitzgerald
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SLC25A33 antibody - 70R-10096 from Fitzgerald
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SLC25A33 antibody (OAGA00533) - OAGA00533 from Aviva Systems Biology
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SLC25A33 / PNC1 antibody - 17794-1-AP from Acris Antibodies
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Anti-SLC25A33 Antibody - AC11-0144 from Abcore
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Rabbit Anti-Human SLC25A33 - 107-10645 from RayBiotech
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SLC25A33 antibody - 17794-1-AP from Proteintech Group
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SLC25A33 - MBS273256 from MyBioSource
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SLC25A33, Polyclonal Antibody - MBS835548 from MyBioSource
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mitochondrial carrier protein MGC4399 antibody - 23159 from Signalway Antibody
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SLC25A33 Antibody - GWB-MV973A from Genway Biotech
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Rabbit Anti-Human SLC25A33 Polyclonal antibody - DPABH-10593 from Creative Diagnostics
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Anti-SLC25A33 (aa 114-320) polyclonal antibody - DPABH-19820 from Creative Diagnostics
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Anti-SLC25A33 monoclonal antibody - DCABH-201486 from Creative Diagnostics
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