| Gene Symbol |
SLC25A33
|
| Entrez Gene |
84275
|
| Alt Symbol |
BMSC-MCP, PNC1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 25 (pyrimidine nucleotide carrier), member 33
|
| Other Description |
PNC1 protein|bone marrow stromal cell mitochondrial carrier protein|huBMSC-MCP|mitochondrial carrier protein|novel mitochondrial carrier protein|solute carrier family 25 member 33|solute carrier family 25, member 33
|
| Swissprots |
Q9BSK2
|
| Accessions |
EAW71620 Q9BSK2 AF495714 AAM18051 AJ880283 CAI54244 BC004991 AAH04991 BC073135 AAH73135 XM_005263503 XP_005263560 XM_011542296 XP_011540598 NM_032315 NP_115691
|
| Function |
Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria (PubMed:25320081). Transports preferentially uracil, thymine, and cytosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism (PubMed:25320081). Also transports guanine but not adenine (deoxy)nucleotides (PubMed:25320081). Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10- phenanthroline, tannic acid, and mercurials (mercury dichloride, mersalyl acid, p-hydroxymercuribenzoate) (PubMed:25320081). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration (PubMed:20453889). Upon INS or IGF1 stimulation regulates cell growth and proliferation by controlling mitochondrial DNA replication and transcription, the ratio of mitochondria-to nuclear-encoded components of the electron transport chain resulting in control of mitochondrial ROS production (PubMed:20453889, PubMed:17596519). Participates in d
|
| Subcellular Location |
Mitochondrion inner membrane {ECO:0000305|PubMed:14715278}; Multi-pass membrane protein {ECO:0000255}.
|
| Tissue Specificity |
Expressed in the central nervous system. Also expressed in testis and skeletal muscle. Weakly expressed in heart, liver, kidney, prostate, colon and peripheral blood leukocytes. {ECO:0000269|PubMed:14715278}.
|