Gene Symbol | SLC25A33 |
---|---|
Entrez Gene | 84275 |
Alt Symbol | BMSC-MCP, PNC1 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 25 (pyrimidine nucleotide carrier), member 33 |
Other Description | PNC1 protein|bone marrow stromal cell mitochondrial carrier protein|huBMSC-MCP|mitochondrial carrier protein|novel mitochondrial carrier protein|solute carrier family 25 member 33|solute carrier family 25, member 33 |
Swissprots | Q9BSK2 |
Accessions | EAW71620 Q9BSK2 AF495714 AAM18051 AJ880283 CAI54244 BC004991 AAH04991 BC073135 AAH73135 XM_005263503 XP_005263560 XM_011542296 XP_011540598 NM_032315 NP_115691 |
Function | Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria (PubMed:25320081). Transports preferentially uracil, thymine, and cytosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism (PubMed:25320081). Also transports guanine but not adenine (deoxy)nucleotides (PubMed:25320081). Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10- phenanthroline, tannic acid, and mercurials (mercury dichloride, mersalyl acid, p-hydroxymercuribenzoate) (PubMed:25320081). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration (PubMed:20453889). Upon INS or IGF1 stimulation regulates cell growth and proliferation by controlling mitochondrial DNA replication and transcription, the ratio of mitochondria-to nuclear-encoded components of the electron transport chain resulting in control of mitochondrial ROS production (PubMed:20453889, PubMed:17596519). Participates in d |
Subcellular Location | Mitochondrion inner membrane {ECO:0000305|PubMed:14715278}; Multi-pass membrane protein {ECO:0000255}. |
Tissue Specificity | Expressed in the central nervous system. Also expressed in testis and skeletal muscle. Weakly expressed in heart, liver, kidney, prostate, colon and peripheral blood leukocytes. {ECO:0000269|PubMed:14715278}. |
SLC25A33 CRISPR/Cas9 KO Plasmid (h) - sc-413606 from Santa Cruz Biotechnology
|
||||||||
SLC25A33 HDR Plasmid (h) - sc-413606-HDR from Santa Cruz Biotechnology
|
||||||||
SLC25A33 Double Nickase Plasmid (h) - sc-413606-NIC from Santa Cruz Biotechnology
|
||||||||
SLC25A33 Double Nickase Plasmid (h2) - sc-413606-NIC-2 from Santa Cruz Biotechnology
|
||||||||
SLC25A33 CRISPR Activation Plasmid (h) - sc-413606-ACT from Santa Cruz Biotechnology
|
||||||||
SLC25A33 CRISPR Activation Plasmid (h2) - sc-413606-ACT-2 from Santa Cruz Biotechnology
|
||||||||
SLC25A33 Lentiviral Activation Particles (h) - sc-413606-LAC from Santa Cruz Biotechnology
|
||||||||
SLC25A33 Lentiviral Activation Particles (h2) - sc-413606-LAC-2 from Santa Cruz Biotechnology
|
||||||||
SLC25A33 siRNA (h) - sc-78559 from Santa Cruz Biotechnology
|
||||||||
SLC25A33 shRNA Plasmid (h) - sc-78559-SH from Santa Cruz Biotechnology
|
||||||||
SLC25A33 shRNA (h) Lentiviral Particles - sc-78559-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU160961 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN19503 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19503 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR01935 from Sigma-Aldrich
|
||||||||
SLC25A33 siRNA (Human) - CRJ3401 from Cohesion Biosciences
|
||||||||
SLC25A33 - MBS8204389 from MyBioSource
|
||||||||
shRNA set against Human SLC25A33 (NM_032315.2) - SHH409692 from Creative biogene
|
||||||||
shRNA set against Human SLC25A33(NM_032315.2) - SHL003574 from Creative biogene
|
||||||||
SLC25A33 shRNA Plasmid (Human) - CHJ3401 from Cohesion Biosciences
|
||||||||
SLC25A33 miRNA 3'UTR clone - MiUTR1H-09482 from Creative biogene
|