Gene Symbol | GRPR |
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Entrez Gene | 2925 |
Alt Symbol | BB2 |
Species | Human |
Gene Type | protein-coding |
Description | gastrin-releasing peptide receptor |
Other Description | GRP-R|GRP-preferring bombesin receptor|bombesin receptor 2 |
Swissprots | B2R910 P30550 |
Accessions | AAB27329 AAL96377 EAW98909 P30550 AK313588 BAG36357 AU125660 BC074733 AAH74733 KJ534854 AHW56494 KJ534855 AHW56495 M73481 AAA88050 U57365 AAB40612 NM_005314 NP_005305 |
Function | Receptor for gastrin releasing peptide (GRP). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Highly expressed in pancreas. Also expressed in stomach, adrenal cortex and brain. {ECO:0000269|PubMed:11245983}. |
Top Pathways | Calcium signaling pathway, Neuroactive ligand-receptor interaction |
GRPR CRISPR/Cas9 KO Plasmid (h) - sc-401637 from Santa Cruz Biotechnology
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GRPR HDR Plasmid (h) - sc-401637-HDR from Santa Cruz Biotechnology
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GRPR Double Nickase Plasmid (h) - sc-401637-NIC from Santa Cruz Biotechnology
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GRPR Double Nickase Plasmid (h2) - sc-401637-NIC-2 from Santa Cruz Biotechnology
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GRPR CRISPR Activation Plasmid (h) - sc-401637-ACT from Santa Cruz Biotechnology
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GRPR CRISPR Activation Plasmid (h2) - sc-401637-ACT-2 from Santa Cruz Biotechnology
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GRPR Lentiviral Activation Particles (h) - sc-401637-LAC from Santa Cruz Biotechnology
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GRPR Lentiviral Activation Particles (h2) - sc-401637-LAC-2 from Santa Cruz Biotechnology
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GRPR siRNA (h) - sc-106924 from Santa Cruz Biotechnology
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GRPR shRNA Plasmid (h) - sc-106924-SH from Santa Cruz Biotechnology
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GRPR shRNA (h) Lentiviral Particles - sc-106924-V from Santa Cruz Biotechnology
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Gastrin-releasing Peptide R/GRPR RNAi - H00002925-R02 from Novus Biologicals
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MISSION® esiRNA - EHU017121 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2281 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2281 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07155 from Sigma-Aldrich
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GRPR siRNA (Human) - CRH1977 from Cohesion Biosciences
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GRPR - MBS8200098 from MyBioSource
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GRPR CRISPR/Cas9 KO Plasmid (h2) - sc-401637-KO-2 from Santa Cruz Biotechnology
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GRPR HDR Plasmid (h2) - sc-401637-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human GRPR (NM_005314.2) - SHH308238 from Creative biogene
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shRNA set against Human GRPR(NM_005314.2) - SHH106217 from Creative biogene
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GRPR shRNA Plasmid (Human) - CHH1977 from Cohesion Biosciences
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GRPR miRNA 3'UTR clone - MiUTR1H-04298 from Creative biogene
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