| Gene Symbol | GUCA1B |
|---|---|
| Entrez Gene | 2979 |
| Alt Symbol | GCAP2, GUCA2, RP48 |
| Species | Human |
| Gene Type | protein-coding |
| Description | guanylate cyclase activator 1B (retina) |
| Other Description | GCAP 2|guanylate cyclase-activating protein, photoreceptor 2|guanylyl cyclase-activating protein 2 |
| Swissprots | Q9UMX6 Q9NU15 |
| Accessions | AAD47279 EAX04085 Q9UMX6 BC166640 AAI66640 BQ636025 BX537393 CAD97635 XM_011514540 XP_011512842 NM_002098 NP_002089 |
| Function | Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low, and GC1 and GC2 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure. |
| Subcellular Location | Cell membrane. Note=Membranes of outer segment. |
| Tissue Specificity | Retina. Cones and rod. |
| Top Pathways | Olfactory transduction, Phototransduction |