Gene Symbol | GUCA1B |
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Entrez Gene | 2979 |
Alt Symbol | GCAP2, GUCA2, RP48 |
Species | Human |
Gene Type | protein-coding |
Description | guanylate cyclase activator 1B (retina) |
Other Description | GCAP 2|guanylate cyclase-activating protein, photoreceptor 2|guanylyl cyclase-activating protein 2 |
Swissprots | Q9UMX6 Q9NU15 |
Accessions | AAD47279 EAX04085 Q9UMX6 BC166640 AAI66640 BQ636025 BX537393 CAD97635 XM_011514540 XP_011512842 NM_002098 NP_002089 |
Function | Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low, and GC1 and GC2 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure. |
Subcellular Location | Cell membrane. Note=Membranes of outer segment. |
Tissue Specificity | Retina. Cones and rod. |
Top Pathways | Olfactory transduction, Phototransduction |
GCAP2 CRISPR/Cas9 KO Plasmid (h) - sc-408738 from Santa Cruz Biotechnology
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GCAP2 HDR Plasmid (h) - sc-408738-HDR from Santa Cruz Biotechnology
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GCAP2 Double Nickase Plasmid (h) - sc-408738-NIC from Santa Cruz Biotechnology
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GCAP2 Double Nickase Plasmid (h2) - sc-408738-NIC-2 from Santa Cruz Biotechnology
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GCAP2 CRISPR Activation Plasmid (h) - sc-408738-ACT from Santa Cruz Biotechnology
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GCAP2 CRISPR Activation Plasmid (h2) - sc-408738-ACT-2 from Santa Cruz Biotechnology
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GCAP2 Lentiviral Activation Particles (h) - sc-408738-LAC from Santa Cruz Biotechnology
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GCAP2 Lentiviral Activation Particles (h2) - sc-408738-LAC-2 from Santa Cruz Biotechnology
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GCAP2 siRNA (h) - sc-40630 from Santa Cruz Biotechnology
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GCAP2 shRNA Plasmid (h) - sc-40630-SH from Santa Cruz Biotechnology
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GCAP2 shRNA (h) Lentiviral Particles - sc-40630-V from Santa Cruz Biotechnology
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GCAP2 RNAi - H00002979-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN9794 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9794 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10221 from Sigma-Aldrich
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GUCA1B siRNA (Human) - CRH2018 from Cohesion Biosciences
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GUCA1B - MBS8229632 from MyBioSource
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shRNA set against Human GUCA1B (NM_002098.5) - SHH309282 from Creative biogene
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GUCA1B shRNA Plasmid (Human) - CHH2018 from Cohesion Biosciences
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GUCA1B miRNA 3'UTR clone - MiUTR4H-TG04056 from Creative biogene
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