SNCAIP

Gene Symbol	SNCAIP
Entrez Gene	9627
Alt Symbol	SYPH1, Sph1
Species	Human
Gene Type	protein-coding
Description	synuclein, alpha interacting protein
Other Description	alpha-synuclein-interacting protein|synphilin-1
Swissprots	D3DSZ1 Q05BS1 Q6L985 Q9Y6H5 Q6L984 Q504U9 Q9HC59 Q1PSC2 Q49AC6 Q6L986
Accessions	AAG17478 EAW48887 EAW48888 EAW48889 EAW48890 EAW48891 Q9Y6H5 AB110788 BAD19017 AB110789 BAD19018 AB110790 BAD19019 AB110791 BAD19020 AB110792 BAD19021 AB110793 BAD19022 AB110794 BAD19023 AF076929 AAD30362 AI702863 AK001617 BAA91791 AK021944 BAG51060 AK298882 BAH12894 AK299687 BAH13102 AK304646 BAH14231 AK310835 BC033743 AAH33743 BC040552 AAH40552 BC094759 AAH94759 BM908442 DQ227317 ABB51162 N21998 XM_005272138 XP_005272195 XM_005272139 XP_005272196 XM_006714734 XP_006714797 XM_011543736 XP_011542038 XM_011543737 XP_011542039 XM_011543738 XP_011542040 XM_011543739 XP_011542041 XM_011543740 XP_011542042 XM_011543741 XP_011542043 XM_011543742 XP_011542044 XM_011543743 XP_011542045 XM_011543744 XP_011542046 XM_011543745 XP_011542047 XM_011543746 XP_011542048 XM_011543747 XP_011542049 XM_011543748 XP_011542050 XM_011543749 XP_011542051 XM_011543750 XP_011542052 XM_011543751 XP_011542053 NM_001242935 NP_001229864 NM_001308100 NP_001295029 NM_001308105 NP_001295034 NM_001308106 NP_001295035 NM_001308107 NP_001295036 NM_001308108 NP_001295037 NM_001308109 NP_001295038 NM_005460 NP_005451 NR_131761 NR_131762
Function	Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1. {ECO:0000269|PubMed:16595633, ECO:0000269|PubMed:19224863}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:10319874, ECO:0000269|PubMed:15064394, ECO:0000269|PubMed:16595633, ECO:0000269|PubMed:19762560}. Note=Detected in cytoplasmic inclusion bodies, together with SNCA.
Tissue Specificity	Detected in brain (at protein level). Widely expressed, with highest levels in brain, heart and placenta. {ECO:0000269|PubMed:10319874, ECO:0000269|PubMed:16595633}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Synphilin 1 full length protein - ab160582 from Abcam Category Protein Source Wheat germ Species Human

Human Synphilin 1 protein fragment - ab160583 from Abcam Category Protein Source Wheat germ Species Human

SNCAIP / Synphilin 1 Antibody Blocking Peptide - LS-E8233 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Synphilin-1 Protein - H00009627-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Synphilin-1 Protein - H00009627-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Synphilin-1 Peptide - P2059 from Novus Biologicals Category Peptide Species Human

Synphilin-1-SNCAIP-Antibody-C-term-Blocking-Peptide - BP6411b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Synphilin 1 / SNCAIP - H00009627-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Synphilin 1 / SNCAIP - H00009627-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Synphilin 1 / SNCAIP - H00009627-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Synphilin 1 / SNCAIP - H00009627-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SNCAIP fusion protein - Ag12147 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

SNCAIP fusion protein - Ag12217 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human SNCAIP, GST-tagged - SNCAIP-2838H from Creative Biomart Category Protein Source E.coli Species Human

Synphilin 1 Blocking Peptide - CBP2411 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human

Synphilin-1 (R846) Peptide - BS2939P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Synphilin-1(SNCAIP) ,partial - CSB-YP896546HU CSB-EP896546HU CSB-BP896546HU CSB-MP896546HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Synphilin 1 / SNCAIP - TP322425 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Alpha Synuclein C-terminal Peptide (OEMA00015) - OEMA00015 from Aviva Systems Biology Category Peptide Prices $295.00 Sizes 1 mg

Synphilin-1-SNCAIP-Antibody-N-term-Blocking-Peptide - BP6411a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SNCAIP Peptide, Human - M34GP14804H from Creative Peptides Category Peptide Source Synthetic. Species Human

Synphilin-1 (SNCAIP), partial, Recombinant Protein - MBS1334529 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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