SNCAIP

Gene Symbol SNCAIP
Entrez Gene 9627
Alt Symbol SYPH1, Sph1
Species Human
Gene Type protein-coding
Description synuclein, alpha interacting protein
Other Description alpha-synuclein-interacting protein|synphilin-1
Swissprots D3DSZ1 Q05BS1 Q6L985 Q9Y6H5 Q6L984 Q504U9 Q9HC59 Q1PSC2 Q49AC6 Q6L986
Accessions AAG17478 EAW48887 EAW48888 EAW48889 EAW48890 EAW48891 Q9Y6H5 AB110788 BAD19017 AB110789 BAD19018 AB110790 BAD19019 AB110791 BAD19020 AB110792 BAD19021 AB110793 BAD19022 AB110794 BAD19023 AF076929 AAD30362 AI702863 AK001617 BAA91791 AK021944 BAG51060 AK298882 BAH12894 AK299687 BAH13102 AK304646 BAH14231 AK310835 BC033743 AAH33743 BC040552 AAH40552 BC094759 AAH94759 BM908442 DQ227317 ABB51162 N21998 XM_005272138 XP_005272195 XM_005272139 XP_005272196 XM_006714734 XP_006714797 XM_011543736 XP_011542038 XM_011543737 XP_011542039 XM_011543738 XP_011542040 XM_011543739 XP_011542041 XM_011543740 XP_011542042 XM_011543741 XP_011542043 XM_011543742 XP_011542044 XM_011543743 XP_011542045 XM_011543744 XP_011542046 XM_011543745 XP_011542047 XM_011543746 XP_011542048 XM_011543747 XP_011542049 XM_011543748 XP_011542050 XM_011543749 XP_011542051 XM_011543750 XP_011542052 XM_011543751 XP_011542053 NM_001242935 NP_001229864 NM_001308100 NP_001295029 NM_001308105 NP_001295034 NM_001308106 NP_001295035 NM_001308107 NP_001295036 NM_001308108 NP_001295037 NM_001308109 NP_001295038 NM_005460 NP_005451 NR_131761 NR_131762
Function Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1. {ECO:0000269|PubMed:16595633, ECO:0000269|PubMed:19224863}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:10319874, ECO:0000269|PubMed:15064394, ECO:0000269|PubMed:16595633, ECO:0000269|PubMed:19762560}. Note=Detected in cytoplasmic inclusion bodies, together with SNCA.
Tissue Specificity Detected in brain (at protein level). Widely expressed, with highest levels in brain, heart and placenta. {ECO:0000269|PubMed:10319874, ECO:0000269|PubMed:16595633}.

synphilin-1 (F-9) - sc-365741 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
synphilin-1 (F-9): sc-365741. Western blot analysis of synphilin-1 expression in U-87 MG whole cell lysate.

synphilin-1 (K-18) - sc-15452 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
synphilin-1 (K-18): sc-15452. Immunoperoxidase staining of formalin fixed, paraffin-embedded human heart muscle tissue showing cytoplasmic staining of myocytes.

synphilin-1 (H-300) - sc-98296 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
synphilin-1 (H-300): sc-98296. Western blot analysis of synphilin-1 expression in IMR-32 whole cell lysate (A) and mouse brain tissue extract (B).

synphilin-1 (L-20) - sc-34193 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

synphilin-1 (N-19) - sc-15451 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
synphilin-1 (N-19): sc-15451. Immunoperoxidase staining of formalin fixed, paraffin-embedded human heart muscle tissue showing cytoplasmic staining of myocytes.

synphilin-1 (V-19) - sc-34192 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

synphilin-1 (A-22) - sc-130890 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
synphilin-1 (A-22): sc-130890. Western blot analysis of synphilin-1 expression in mouse brain whole cell lysate.

Anti-Synphilin 1 antibody - ab6179 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab6179 stained HeLa cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab6179 at 1/200 dilution overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Synphilin 1 antibody - ab71773 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Synphilin 1 antibody (ab71773) at 1/50 dilution + Mouse brain lysate at 12.5 µg

Anti-Synphilin 1 antibody - ab6178 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Synphilin 1 antibody - ab56627 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab56627 Synphilin 1 antibody at 1ug/ml.

Anti-Synphilin 1 antibody - ab172356 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-Synphilin 1 antibody (ab172356) at 1 µg/mlLane 1 : Synphilin 1 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.developed using the ECL technique

Anti-SNCAIP / Synphilin 1 Antibody (aa829-847) - LS-C11522 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µl
Host Goat
Clonality Polyclonal

Anti-SNCAIP / Synphilin 1 Antibody (aa829-847) - LS-C26321 from LifeSpan Bioscience

Prices $475.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-SNCAIP / Synphilin 1 Antibody - LS-C89916 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SNCAIP / Synphilin 1 Antibody (aa911-919) - LS-C89918 from LifeSpan Bioscience

Prices $495.00
Sizes 1 mg
Host Rabbit
Clonality Polyclonal

Anti-SNCAIP / Synphilin 1 Antibody - LS-C89917 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SNCAIP / Synphilin 1 Antibody (Internal) - LS-C94896 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-SNCAIP / Synphilin 1 Antibody (C-Terminus) - LS-C94898 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-SNCAIP / Synphilin 1 Antibody - LS-C122462 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µl
Host Goat
Clonality Polyclonal

Anti-SNCAIP / Synphilin 1 Antibody (aa797-846) - LS-C291741 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SNCAIP / Synphilin 1 Antibody (aa593-622) - LS-C99203 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
The anti-Synphilin-1 C-term antibody is used in Western blot to detect Synphilin-1 in mouse brain lysate.

Anti-SNCAIP / Synphilin 1 Antibody (Arg846) - LS-C177288 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of Synphilin-1 (R846) pAb in paraffin-embedded lung carcinoma. tissue.

Synphilin-1 Antibody - NBP1-86977 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: Synphilin-1 Antibody [NBP1-86977] Staining of human cell line U-2 OS shows positivity in nucleus, nucleoli & cytoplasm.

Synphilin-1 Antibody - H00009627-B01 from Novus Biologicals

Prices $359.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: Synphilin-1 Antibody [H00009627-B01] - Analysis of SNCAIP expression in transfected 293T cell line. Lane 1: SNCAIP transfected lysate (66.33 KDa). Lane 2: Non-transfected lysate.
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