| Gene Symbol | HOPX |
|---|---|
| Entrez Gene | 84525 |
| Alt Symbol | CAMEO, HOD, HOP, LAGY, NECC1, OB1, SMAP31, TOTO |
| Species | Human |
| Gene Type | protein-coding |
| Description | HOP homeobox |
| Other Description | homeodomain-only protein|lung cancer-associated Y protein|not expressed in choriocarcinoma clone 1|not expressed in choriocarcinoma protein 1|odd homeobox 1 protein|odd homeobox protein 1 |
| Swissprots | E9PB55 Q96CI1 Q9BPY8 Q8N0V6 G3V294 A8K0Z2 |
| Accessions | EAX05503 EAX05505 EAX05511 Q9BPY8 AA504137 AB019573 AB059408 BAB40926 AB059409 BAB40927 AB059410 BAB40928 AF454763 AAL56613 AF492675 AAM46827 AF492676 AAM46828 AF492677 AAM46829 AF492678 AAM46830 AF492679 AAM46831 AF492680 AAM46832 AF492681 AAM46833 AK096707 AK123318 AK289707 BAF82396 AM393649 CAL38525 AW955211 BC014225 AAH14225 CB996541 CK002567 DA512059 DB180848 DQ892193 ABM83119 EB386856 EU176669 ABW03470 XM_006714051 XP_006714114 XM_006714052 XP_006714115 XM_011534407 XP_011532709 XM_011534408 XP_011532710 NM_001145459 NP_001138931 NM_001145460 NP_001138932 NM_032495 NP_115884 NM_139211 NP_631957 NM_139212 NP_631958 |
| Function | Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor. {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}. |
| Tissue Specificity | Widely expressed. Expressed in the heart, brain, placenta, lung, skeletal and smooth muscles, uterus, urinary bladder, kidney and spleen. Down-regulated in some types of cancer such as lung cancer, choriocarcinoma, head and neck squamous cell carcinoma and oral squamous cell carcinoma. {ECO:0000269|PubMed:12573257, ECO:0000269|PubMed:12759545}. |