HS3ST5
| Gene Symbol | HS3ST5 |
|---|---|
| Entrez Gene | 222537 |
| Alt Symbol | 3-OST-5, 3OST5, HS3OST5, NBLA04021 |
| Species | Human |
| Gene Type | protein-coding |
| Description | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 |
| Other Description | h3-OST-5|heparan sulfate 3-O-sulfotransferase 5|heparan sulfate 3-OST-5|heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5|heparan sulfate glucosamine 3-O-sulfotransferase 5 |
| Swissprots | Q52LI2 Q8N285 Q8IZT8 A8K1J2 |
| Accessions | EAW48251 Q8IZT8 AB074164 BAE45734 AF503292 AAN37737 AK091074 AK126930 AK289907 BAF82596 BC093911 AAH93911 BC093913 AAH93913 XM_006715379 XP_006715442 XM_011535587 XP_011533889 XM_011535588 XP_011533890 XR_942347 NM_153612 NP_705840 |
| Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Also generates GlcUA- GlcNS or IdoUA-GlcNS and IdoUA2S-GlcNH2. The substrate-specific O- sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. {ECO:0000269|PubMed:12138164}. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. |
| Tissue Specificity | Highly expressed in skeletal muscle and fetal brain, and also found in adult brain, spinal cord, cerebellum and colon. {ECO:0000269|PubMed:12138164, ECO:0000269|PubMed:12740361}. |
| Top Pathways | Glycosaminoglycan biosynthesis - heparan sulfate / heparin |
HS3ST5 (C-12) - sc-107614 from Santa Cruz Biotechnology
|
||||||||
HS3ST5 (N-14) - sc-107615 from Santa Cruz Biotechnology
|
||||||||
HS3ST5 (B-21) - sc-133676 from Santa Cruz Biotechnology
|
||||||||
Anti-HS3ST5 antibody - ab105776 from Abcam
|
||||||||
Anti-HS3ST5 / 3OST5 Antibody (C-Terminus) - LS-C82561 from LifeSpan Bioscience
|
||||||||
HS3ST5 Antibody - NBP1-89373 from Novus Biologicals
![Western Blot: HS3ST5 Antibody [NBP1-89373] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).](http://www.bioprodhub.com/system/product_images/ab_products/5/sub_8/16075_HS3ST5%2520Antibody-Western%2520Blot-NBP1-89373-img0005.jpg)
|
||||||||
HS3ST5 Antibody - NBP1-69629 from Novus Biologicals
|
||||||||
Anti-HS3ST5 antibody produced in rabbit - AV49083 from Sigma-Aldrich
|
||||||||
Anti-HS3ST5 antibody produced in rabbit - HPA021823 from Sigma-Aldrich
|
||||||||
HS3ST5 antibody - C-terminal region (ARP49083_P050) - ARP49083_P050 from Aviva Systems Biology
|
||||||||
HS3ST5 antibody, C-term - GTX46133 from GeneTex
|
||||||||
HS3ST6 antibody, C-term - GTX46226 from GeneTex
|
||||||||
HS3ST5 antibody - 70R-7454 from Fitzgerald
|
||||||||
HS3ST6 antibody - 70R-2842 from Fitzgerald
|
||||||||
HS3ST5 Antibody - 30-503 from ProSci
|
||||||||
HS3ST5 antibody - 17961-1-AP from Proteintech Group
|
||||||||
HS3ST5 Antibody - GWB-MR398B from Genway Biotech
|
||||||||
HS3ST5 Antibody - EPP14093 from Elabscience
|
||||||||
Anti-HS3ST5 monoclonal antibody - DCABH-11932 from Creative Diagnostics
|
||||||||
HS3ST5, Polyclonal Antibody - MBS2524207 from MyBioSource
|
||||||||
HS3ST5 / 3OST5 antibody - TA330989 from Acris Antibodies
|
||||||||
Anti-HS3ST5 (aa 280-329) polyclonal antibody - CABT-BL4880 from Creative Diagnostics
|
||||||||
Anti-HS3ST5 Antibody A11166 - A11166 from Boster Bio
|
||||||||
HS3ST5 Antibody - NBP2-55930 from Novus Biologicals
|
||||||||
HS3ST5 antibody - C-terminal region : Biotin (ARP49083_P050-Biotin) - ARP49083_P050-Biotin from Aviva Systems Biology
|