| Gene Symbol |
HS3ST5
|
| Entrez Gene |
222537
|
| Alt Symbol |
3-OST-5, 3OST5, HS3OST5, NBLA04021
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
|
| Other Description |
h3-OST-5|heparan sulfate 3-O-sulfotransferase 5|heparan sulfate 3-OST-5|heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5|heparan sulfate glucosamine 3-O-sulfotransferase 5
|
| Swissprots |
Q52LI2 Q8N285 Q8IZT8 A8K1J2
|
| Accessions |
EAW48251 Q8IZT8 AB074164 BAE45734 AF503292 AAN37737 AK091074 AK126930 AK289907 BAF82596 BC093911 AAH93911 BC093913 AAH93913 XM_006715379 XP_006715442 XM_011535587 XP_011533889 XM_011535588 XP_011533890 XR_942347 NM_153612 NP_705840
|
| Function |
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Also generates GlcUA- GlcNS or IdoUA-GlcNS and IdoUA2S-GlcNH2. The substrate-specific O- sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. {ECO:0000269|PubMed:12138164}.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Highly expressed in skeletal muscle and fetal brain, and also found in adult brain, spinal cord, cerebellum and colon. {ECO:0000269|PubMed:12138164, ECO:0000269|PubMed:12740361}.
|
| Top Pathways |
Glycosaminoglycan biosynthesis - heparan sulfate / heparin
|
