HS3ST5

Gene Symbol HS3ST5
Entrez Gene 222537
Alt Symbol 3-OST-5, 3OST5, HS3OST5, NBLA04021
Species Human
Gene Type protein-coding
Description heparan sulfate (glucosamine) 3-O-sulfotransferase 5
Other Description h3-OST-5|heparan sulfate 3-O-sulfotransferase 5|heparan sulfate 3-OST-5|heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5|heparan sulfate glucosamine 3-O-sulfotransferase 5
Swissprots Q52LI2 Q8N285 Q8IZT8 A8K1J2
Accessions EAW48251 Q8IZT8 AB074164 BAE45734 AF503292 AAN37737 AK091074 AK126930 AK289907 BAF82596 BC093911 AAH93911 BC093913 AAH93913 XM_006715379 XP_006715442 XM_011535587 XP_011533889 XM_011535588 XP_011533890 XR_942347 NM_153612 NP_705840
Function Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Also generates GlcUA- GlcNS or IdoUA-GlcNS and IdoUA2S-GlcNH2. The substrate-specific O- sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. {ECO:0000269|PubMed:12138164}.
Subcellular Location Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Tissue Specificity Highly expressed in skeletal muscle and fetal brain, and also found in adult brain, spinal cord, cerebellum and colon. {ECO:0000269|PubMed:12138164, ECO:0000269|PubMed:12740361}.
Top Pathways Glycosaminoglycan biosynthesis - heparan sulfate / heparin

HS3ST5 CRISPR/Cas9 KO Plasmid (h) - sc-415157 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HS3ST5 HDR Plasmid (h) - sc-415157-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HS3ST5 Double Nickase Plasmid (h) - sc-415157-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HS3ST5 Double Nickase Plasmid (h2) - sc-415157-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HS3ST5 CRISPR Activation Plasmid (h) - sc-415157-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HS3ST5 CRISPR Activation Plasmid (h2) - sc-415157-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HS3ST5 Lentiviral Activation Particles (h) - sc-415157-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HS3ST5 Lentiviral Activation Particles (h2) - sc-415157-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HS3ST5 siRNA (h) - sc-95068 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HS3ST5 shRNA Plasmid (h) - sc-95068-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HS3ST5 shRNA (h) Lentiviral Particles - sc-95068-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU019301 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10311 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10311 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

HS3ST5 siRNA (Human) - CRJ6567 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HS3ST5 - MBS8206424 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human HS3ST5 siRNA - orb277068 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HS3ST5 shRNA Plasmid (Human) - CHJ6567 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

HS3ST5 miRNA 3'UTR clone - MiUTR3H-10594 from Creative biogene

Species Reactivities Human
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