| Gene Symbol |
SLC47A2
|
| Entrez Gene |
146802
|
| Alt Symbol |
MATE2, MATE2-B, MATE2-K, MATE2K
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 47 (multidrug and toxin extrusion), member 2
|
| Other Description |
H+/organic cation antiporter|MATE-2|hMATE-2|kidney-specific H(+)/organic cation antiporter|multidrug and toxin extrusion 2|multidrug and toxin extrusion protein 2|solute carrier family 47, member 2
|
| Swissprots |
Q96NA1 Q86VL8 Q63HJ9 Q8IV44 A0P8Z7 A0JBX9
|
| Accessions |
EAW50901 EAW50902 EAW50903 EAW50904 EAW50905 EAW50906 EAW50907 Q86VL8 AB250364 BAF36847 AB250701 BAF37007 AK055758 AK096080 AK123589 AK307647 AK310218 BC035288 AAH35288 BC050578 AAH50578 BC062614 BG432484 BM924669 BM930596 BX648861 CAH56154 DA312379 XM_006721455 XP_006721518 XM_006721457 XP_006721520 XM_011523672 XP_011521974 XM_011523673 XP_011521975 XM_011523674 XP_011521976 XM_011523675 XP_011521977 XR_243543 XR_933998 XR_933999 XR_934000 XR_934001 NM_001099646 NP_001093116 NM_001256663 NP_001243592 NM_152908 NP_690872
|
| Function |
Solute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes. {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:16996621, ECO:0000269|PubMed:17509534}.
|
| Subcellular Location |
Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Localized at the brush border membranes of the proximal tubules.
|
| Tissue Specificity |
Isoform 3 is predominantly expressed in kidney. Isoform 6 is expressed in brain. {ECO:0000269|PubMed:16807400}.
|