MBTPS2

Gene Symbol	MBTPS2
Entrez Gene	51360
Alt Symbol	BRESEK, IFAP, KFSD, KFSDX, OLMSX, S2P
Species	Human
Gene Type	protein-coding
Description	membrane-bound transcription factor peptidase, site 2
Other Description	SREBPs intramembrane protease|endopeptidase S2P|keratosis follicularis spinulosa decalvans|membrane-bound transcription factor protease, site 2|membrane-bound transcription factor site-2 protease|sterol regulatory element-binding proteins intramembrane protease
Swissprots	O43462 Q9UMD3 Q9UM70
Accessions	AAD08631 AAD08632 EAW98982 O43462 AF019612 AAC51937 AK056736 AK292933 BAF85622 AK307143 AK312474 AW204540 AW664372 BC036465 BX489533 DC338559 NM_015884 NP_056968
Function	Intramembrane proteolysis of sterol-regulatory element- binding proteins (SREBPs) within the first transmembrane segment thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Site-2 cleavage comes after site-1 cleavage which takes place in the lumenal loop.
Subcellular Location	Membrane {ECO:0000305|PubMed:19361614}; Multi-pass membrane protein {ECO:0000305|PubMed:19361614}. Cytoplasm {ECO:0000269|PubMed:19361614}.
Tissue Specificity	Expressed in heart, brain, placenta, lung, liver, muscle, kidney and pancreas.
Top Pathways	Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MBTPS2 Antibody - 2157 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

S2P (N-20) - sc-10863 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-S2P antibody - ab140594 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-S2P antibody - ab76641 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-S2P antibody - ab196797 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-S2P antibody - ab189797 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-S2P antibody - N-terminal - ab171547 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-MBTPS2 Antibody (aa15-44, FITC) - LS-C208959 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MBTPS2 Antibody (aa15-44, APC) - LS-C207227 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MBTPS2 Antibody (aa312-419) - LS-C308909 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-MBTPS2 Antibody (aa15-44, AP) - LS-C207226 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MBTPS2 Antibody (aa15-44, Biotin) - LS-C207228 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MBTPS2 Antibody (aa15-44, Azide-free, HRP) - LS-C208961 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MBTPS2 Antibody (aa301-350) - LS-C120078 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MBTPS2 Antibody (aa15-44, PE) - LS-C208962 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MBTPS2 Antibody (aa14-44) - LS-C322895 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MBTPS2 Antibody (aa15-44) - LS-C164068 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

MBTPS2 Antibody (1A3) - H00051360-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1A3

MBTPS2 Antibody - NBP1-80800 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Monoclonal Anti-MBTPS2 antibody produced in mouse - SAB1403245 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1A3

Anti-MBTPS2 antibody produced in rabbit - SAB4502122 from Sigma-Aldrich Prices $335.50 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MBTPS2 antibody produced in rabbit - HPA005494 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

MBTPS2-Antibody-N-term - AP12972a from Abgent, a WuXi AppTec company Prices $99.00, $295.00 Sizes 80 µl, 400 µl Host Rabbit Clonality Polyclonal

MBTPS2 antibody - GTX86983 from GeneTex Prices $319.00 Sizes 100 μg Host Rabbit Clonality Polyclonal

MBTPS2 Antibody - N-terminal region (OAAB09258) - OAAB09258 from Aviva Systems Biology Prices $289.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

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