MBTPS2

Gene Symbol MBTPS2
Entrez Gene 51360
Alt Symbol BRESEK, IFAP, KFSD, KFSDX, OLMSX, S2P
Species Human
Gene Type protein-coding
Description membrane-bound transcription factor peptidase, site 2
Other Description SREBPs intramembrane protease|endopeptidase S2P|keratosis follicularis spinulosa decalvans|membrane-bound transcription factor protease, site 2|membrane-bound transcription factor site-2 protease|sterol regulatory element-binding proteins intramembrane protease
Swissprots O43462 Q9UMD3 Q9UM70
Accessions AAD08631 AAD08632 EAW98982 O43462 AF019612 AAC51937 AK056736 AK292933 BAF85622 AK307143 AK312474 AW204540 AW664372 BC036465 BX489533 DC338559 NM_015884 NP_056968
Function Intramembrane proteolysis of sterol-regulatory element- binding proteins (SREBPs) within the first transmembrane segment thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Site-2 cleavage comes after site-1 cleavage which takes place in the lumenal loop.
Subcellular Location Membrane {ECO:0000305|PubMed:19361614}; Multi-pass membrane protein {ECO:0000305|PubMed:19361614}. Cytoplasm {ECO:0000269|PubMed:19361614}.
Tissue Specificity Expressed in heart, brain, placenta, lung, liver, muscle, kidney and pancreas.
Top Pathways Protein processing in endoplasmic reticulum

S2P CRISPR/Cas9 KO Plasmid (h) - sc-409938 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

S2P HDR Plasmid (h) - sc-409938-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

S2P Double Nickase Plasmid (h) - sc-409938-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

S2P Double Nickase Plasmid (h2) - sc-409938-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

S2P CRISPR Activation Plasmid (h) - sc-409938-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

S2P CRISPR Activation Plasmid (h2) - sc-409938-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

S2P Lentiviral Activation Particles (h) - sc-409938-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

S2P Lentiviral Activation Particles (h2) - sc-409938-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

S2P siRNA (h) - sc-41652 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

S2P shRNA Plasmid (h) - sc-41652-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

S2P shRNA (h) Lentiviral Particles - sc-41652-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MBTPS2 RNAi - H00051360-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU032591 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2409 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2409 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MBTPS2 siRNA (Human) - CRH9719 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human MBTPS2 (NM_015884.3) - SHH339015 from Creative biogene

Category siRNA
Species Reactivities Human

Human MBTPS2 siRNA - orb270221 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MBTPS2 shRNA Plasmid (Human) - CHH9719 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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