MBTPS2

Gene Symbol	MBTPS2
Entrez Gene	51360
Alt Symbol	BRESEK, IFAP, KFSD, KFSDX, OLMSX, S2P
Species	Human
Gene Type	protein-coding
Description	membrane-bound transcription factor peptidase, site 2
Other Description	SREBPs intramembrane protease|endopeptidase S2P|keratosis follicularis spinulosa decalvans|membrane-bound transcription factor protease, site 2|membrane-bound transcription factor site-2 protease|sterol regulatory element-binding proteins intramembrane protease
Swissprots	O43462 Q9UMD3 Q9UM70
Accessions	AAD08631 AAD08632 EAW98982 O43462 AF019612 AAC51937 AK056736 AK292933 BAF85622 AK307143 AK312474 AW204540 AW664372 BC036465 BX489533 DC338559 NM_015884 NP_056968
Function	Intramembrane proteolysis of sterol-regulatory element- binding proteins (SREBPs) within the first transmembrane segment thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Site-2 cleavage comes after site-1 cleavage which takes place in the lumenal loop.
Subcellular Location	Membrane {ECO:0000305|PubMed:19361614}; Multi-pass membrane protein {ECO:0000305|PubMed:19361614}. Cytoplasm {ECO:0000269|PubMed:19361614}.
Tissue Specificity	Expressed in heart, brain, placenta, lung, liver, muscle, kidney and pancreas.
Top Pathways	Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human S2P full length protein - ab162519 from Abcam Category Protein Source Wheat germ Species Human

Human S2P protein fragment - ab162520 from Abcam Category Protein Source Wheat germ Species Human

MBTPS2 Antibody Blocking Peptide - LS-E2082 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MBTPS2 Protein - H00051360-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human MBTPS2 Protein - H00051360-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

MBTPS2-Antibody-N-term-Blocking-peptide - BP12972a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MBTPS2 - H00051360-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

MBTPS2 - H00051360-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

MBTPS2 - H00051360-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

MBTPS2 fusion protein - ag3404 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

MBTPS2 fusion protein - ag4390 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Human MBTPS2 Antibody - GWB-ASE701 from Genway Biotech Category Protein Prices $180.00, $300.00 Sizes 50 μg, 100 μg Source Rabbit Species Human

MBTPS2 Blocking Peptide - CBP4082 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine

MBTPS2 Recombinant Protein Antigen - NBP1-80800PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

MBTPS2 Blocking Peptide - abx162575 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine

MBTPS2 Peptide, Human - M34GP09293H from Creative Peptides Category Peptide Source Synthetic. Species Human

MBTPS2 peptide - orb256969 from Biorbyt Category Peptide Prices $272.00, $519.00 Sizes 1 mg, 5 mg

Membrane-bound transcription factor site-2 protease (MBTPS2), Recombinant Protein - MBS1092768 from MyBioSource Category Protein Prices $1,375.00, $1,835.00 Sizes 1 mg (E-Coli), 1 mg (Yeast) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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