| Gene Symbol | NTRK3 |
|---|---|
| Entrez Gene | 4916 |
| Alt Symbol | GP145-TrkC, TRKC, gp145(trkC) |
| Species | Human |
| Gene Type | protein-coding |
| Description | neurotrophic tyrosine kinase, receptor, type 3 |
| Other Description | ETS related protein-neurotrophic receptor tyrosine kinase fusion protein|ETV6-NTRK3 fusion|NT-3 growth factor receptor|tyrosine kinase receptor C |
| Swissprots | Q16288 Q12827 Q16289 O75682 H0YND1 E9PG56 B7Z4C5 |
| Accessions | CAA12029 EAX01989 EAX01990 EAX01991 EAX01992 EAX01993 Q16288 AF052184 AF058389 AAC97478 AF058390 AAC97479 AF125808 AAF19762 AI613045 AK297160 BAH12511 AK302504 BAH13730 AK309695 AK313646 AL134171 AY065844 AAL40893 BC013693 AAH13693 BC128249 BG741347 BI962878 BM675026 BM887782 BQ893817 BT007291 AAP35955 CB053605 CK903553 DA789502 DQ323597 ABD27898 KJ534904 AHW56544 KJ534905 AHW56545 KJ534906 AHW56546 KJ535052 AHW56691 S76475 AAB33111 S76476 AAB33112 U05012 AAA75374 XM_006720543 XP_006720606 XM_006720544 XP_006720607 XM_006720545 XP_006720608 XM_006720546 XP_006720609 XM_006720547 XP_006720610 XM_006720548 XP_006720611 XM_006720549 XP_006720612 XM_006720550 XP_006720613 XM_011521634 XP_011519936 XM_011521635 XP_011519937 XM_011521636 XP_011519938 XM_011521637 XP_011519939 XM_011521638 XP_011519940 XR_931841 XR_931842 NM_001007156 NP_001007157 NM_001012338 NP_001012338 NM_001243101 NP_001230030 NM_002530 NP_002521 |
| Function | Receptor for neurotrophin-3 (NT-3). This is a tyrosine- protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain. |
| Top Pathways | Neurotrophin signaling pathway, Central carbon metabolism in cancer |