NTRK3

Gene Symbol NTRK3
Entrez Gene 4916
Alt Symbol GP145-TrkC, TRKC, gp145(trkC)
Species Human
Gene Type protein-coding
Description neurotrophic tyrosine kinase, receptor, type 3
Other Description ETS related protein-neurotrophic receptor tyrosine kinase fusion protein|ETV6-NTRK3 fusion|NT-3 growth factor receptor|tyrosine kinase receptor C
Swissprots Q16288 Q12827 Q16289 O75682 H0YND1 E9PG56 B7Z4C5
Accessions CAA12029 EAX01989 EAX01990 EAX01991 EAX01992 EAX01993 Q16288 AF052184 AF058389 AAC97478 AF058390 AAC97479 AF125808 AAF19762 AI613045 AK297160 BAH12511 AK302504 BAH13730 AK309695 AK313646 AL134171 AY065844 AAL40893 BC013693 AAH13693 BC128249 BG741347 BI962878 BM675026 BM887782 BQ893817 BT007291 AAP35955 CB053605 CK903553 DA789502 DQ323597 ABD27898 KJ534904 AHW56544 KJ534905 AHW56545 KJ534906 AHW56546 KJ535052 AHW56691 S76475 AAB33111 S76476 AAB33112 U05012 AAA75374 XM_006720543 XP_006720606 XM_006720544 XP_006720607 XM_006720545 XP_006720608 XM_006720546 XP_006720609 XM_006720547 XP_006720610 XM_006720548 XP_006720611 XM_006720549 XP_006720612 XM_006720550 XP_006720613 XM_011521634 XP_011519936 XM_011521635 XP_011519937 XM_011521636 XP_011519938 XM_011521637 XP_011519939 XM_011521638 XP_011519940 XR_931841 XR_931842 NM_001007156 NP_001007157 NM_001012338 NP_001012338 NM_001243101 NP_001230030 NM_002530 NP_002521
Function Receptor for neurotrophin-3 (NT-3). This is a tyrosine- protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.
Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain.
Top Pathways Neurotrophin signaling pathway, Central carbon metabolism in cancer

TrkC (C44H5) Rabbit mAb - 3376 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C44H5
Western blot analysis of extracts from mouse and rat brain using TrkC (C44H5) Rabbit mAb.

Trk (C-15) - sc-139 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Trk (C-15): sc-139. Western blot analysis of Trk expression in rat brain extract.

Trk C (D-15) - sc-47518 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Trk C (798) - sc-117 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Trk C (798): sc-117. Western blot analysis of Trk C expression in EOC 20 whole cell lysate.

Trk C (H-300) - sc-14025 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Trk C (H-300): sc-14025. Western blot analysis of Trk C expression in EOC 20 whole cell lysate.

Trk C (K-13) - sc-21802 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Trk C (N-13) - sc-47520 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Trk C (N-13): sc-47520. Western blot analysis of Trk C expression in rat brain tissue extract.

Trk C (WW6) - sc-80403 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

Anti-TrkC (phospho Y820) antibody - ab79811 from Abcam

Prices $370.00
Sizes 100 µl
Host Sheep
Clonality Polyclonal
All lanes : Anti-TrkC (phospho Y820) antibody (ab79811) at 1/1000 dilutionLane 1 : rat brain lysateLane 2 : rat brain lysate with pre-absorption of the antibody with the immunising peptide

Anti-TrkC antibody - ab75174 from Abcam

Prices $394.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab75174 at 1/500 dilution stained rat DRG, DAPI counterstained, using Immunofluorescence

Anti-TrkC antibody - ab72120 from Abcam

Host Sheep
Clonality Polyclonal
ab72120 at a 1/500 dilution staining TrkC in rat trigeminal ganglia by Immunocytochemistry/ Immunofluorescence. DAPI counterstained.

Anti-TrkC antibody - ab77495 from Abcam

Host Sheep
Clonality Polyclonal

Anti-TrkC antibody - ab43078 from Abcam

Prices $373.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TrkC antibody - ab77494 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-TrkC antibody - ab33656 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-TrkC antibody [4G5] - ab91193 from Abcam

Host Mouse
Clonality Monoclonal
Clone 4G5
Overlay histogram showing SH-SY5Y cells stained with ab91193 (red line). The cells were fixed with 80% methanol (5 min) and incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab91193, 1/50 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.This antibody gave a positive result in 4% paraformaldehyde (10 min) fixed SH-SY5Y cells used under the same conditions. Please note that Abcam do not have any data for use of this antibody on non-fixed cells. We welcome any customer feedback.

Anti-TrkC antibody [7H6] - ab91190 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7H6
Overlay histogram showing SHSY-5Y cells stained with ab91190 (red line). The cells were fixed with 80% methanol (5 min) and incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab91190, 0.1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive result in 4% paraformaldehyde (10 min) fixed SHSY-5Y cells used under the same conditions. Please note that Abcam do not have any data for use of this antibody on non-fixed cells. We welcome any customer feedback.

Anti-TrkC antibody [MM0587-9R22] - ab89926 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone MM0587-9R22

Anti-TrkC antibody - N-terminal - ab188592 from Abcam

Prices $376.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human adrenal medulla tissue, labeling TrkC with ab188592 at 2.5 µg/ml followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-TrkC antibody - N-terminal - ab135810 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-TrkC antibody - N-terminal (ab135810) at 1/100 dilution + 293 cell lysate at 35 µg

Anti-NTRK3 / TRKC Antibody (PE) - LS-C39860 from LifeSpan Bioscience

Prices $605.00
Sizes 100 tst
Host Goat
Clonality Polyclonal

Anti-NTRK3 / TRKC Antibody (Extracellular Domain) - LS-C86262 from LifeSpan Bioscience

Prices $710.00
Sizes 200 µg
Host Goat
Clonality Polyclonal

Anti-NTRK3 / TRKC Antibody (Extracellular Domain) - LS-C89742 from LifeSpan Bioscience

Prices $635.00
Sizes 100 µg
Host Rat
Clonality Monoclonal

Anti-NTRK3 / TRKC Antibody (phospho-Tyr820) - LS-C95054 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-NTRK3 / TRKC Antibody (Extracellular Domain) - LS-C95044 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Sheep
Clonality Polyclonal
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