Gene Symbol | MAN2A1 |
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Entrez Gene | 4124 |
Alt Symbol | AMan II, GOLIM7, MANA2, MANII |
Species | Human |
Gene Type | protein-coding |
Description | mannosidase, alpha, class 2A, member 1 |
Other Description | Golgi alpha-mannosidase II|alpha-mannosidase 2|golgi integral membrane protein 7|mannosidase, alpha type II|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase |
Swissprots | Q16767 Q16706 |
Accessions | EAW49048 Q16706 AK314090 AL833486 BC031659 BC043416 AAH43416 BC111062 BC142656 AAI42657 BC142696 AAI42697 BX341412 BX643508 CR936691 D63998 BAA10017 U31520 AAC50302 XM_011543394 XP_011541696 XM_011543395 XP_011541697 XR_948262 NM_002372 NP_002363 |
Function | Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway. |
Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
Top Pathways | N-Glycan biosynthesis |
MAN2A1 CRISPR/Cas9 KO Plasmid (h) - sc-408136 from Santa Cruz Biotechnology
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MAN2A1 HDR Plasmid (h) - sc-408136-HDR from Santa Cruz Biotechnology
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MAN2A1 Double Nickase Plasmid (h) - sc-408136-NIC from Santa Cruz Biotechnology
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MAN2A1 Double Nickase Plasmid (h2) - sc-408136-NIC-2 from Santa Cruz Biotechnology
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MAN2A1 CRISPR Activation Plasmid (h) - sc-408136-ACT from Santa Cruz Biotechnology
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MAN2A1 CRISPR Activation Plasmid (h2) - sc-408136-ACT-2 from Santa Cruz Biotechnology
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MAN2A1 Lentiviral Activation Particles (h) - sc-408136-LAC from Santa Cruz Biotechnology
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MAN2A1 Lentiviral Activation Particles (h2) - sc-408136-LAC-2 from Santa Cruz Biotechnology
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MAN2A1 siRNA (h) - sc-61926 from Santa Cruz Biotechnology
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MAN2A1 shRNA Plasmid (h) - sc-61926-SH from Santa Cruz Biotechnology
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MAN2A1 shRNA (h) Lentiviral Particles - sc-61926-V from Santa Cruz Biotechnology
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Alpha-mannosidase II RNAi - H00004124-R01 from Novus Biologicals
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MISSION® esiRNA - EHU138041 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN12965 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12965 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06076 from Sigma-Aldrich
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MAN2A1 siRNA (Human) - CRH2801 from Cohesion Biosciences
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shRNA set against Human MAN2A1 (NM_002372.2) - SHH337299 from Creative biogene
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Human MAN2A1 siRNA - orb263303 from Biorbyt
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MAN2A1 shRNA Plasmid (Human) - CHH2801 from Cohesion Biosciences
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MAN2A1 miRNA 3'UTR clone - MiUTR1H-06036 from Creative biogene
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