WNK4

Gene Symbol	WNK4
Entrez Gene	65266
Alt Symbol	PHA2B, PRKWNK4
Species	Human
Gene Type	protein-coding
Description	WNK lysine deficient protein kinase 4
Other Description	protein kinase lysine-deficient 4|protein kinase with no lysine 4|serine/threonine-protein kinase WNK4
Swissprots	B0LPI0 Q96J92 Q9BYS5 Q96DT8 Q8N8Z2 Q8N8X3
Accessions	ABY87559 EAW60881 EAW60882 Q96J92 AF390018 AAK91995 AJ309861 CAC32991 AJ316534 CAC48387 AK096003 BAC04669 AK096052 BAC04688 AK301963 BAG63376 BC136664 AAI36665 BC144356 BM683764 CA388932 XM_005257595 XP_005257652 XM_005257596 XP_005257653 XM_005257597 XP_005257654 XM_006722020 XP_006722083 XM_006722021 XP_006722084 XM_006722022 XP_006722085 XM_011525132 XP_011523434 XM_011525133 XP_011523435 XM_011525134 XP_011523436 XM_011525135 XP_011523437 NM_032387 NP_115763
Function	Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis. Phosphorylates NEDD4L. {ECO:0000269|PubMed:20525693}.
Subcellular Location	Cell junction, tight junction {ECO:0000250}. Note=Present exclusively in intercellular junctions in the distal convoluted tubule and in both the cytoplasm and intercellular junctions in the cortical collecting duct. WNK4 is part of the tight junction complex (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in kidney, colon and skin. {ECO:0000269|PubMed:11571656}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

WNK4 Antibody - 5713 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

WNK4 (N-12) - sc-20474 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

WNK4 (T-19) - sc-20475 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-WNK4 antibody - ab126477 from Abcam Prices $443.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-WNK4 Antibody (Internal) - LS-C11071 from LifeSpan Bioscience Prices $415.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-WNK4 Antibody (aa200-300) - LS-C90507 from LifeSpan Bioscience Prices $435.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-WNK4 Antibody - LS-C132959 from LifeSpan Bioscience Prices $445.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-WNK4 Antibody (aa200-300, Biotin) - LS-C142341 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-WNK4 Antibody (aa200-300, DY650) - LS-C142342 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-WNK4 Antibody (aa200-300, DY488) - LS-C142343 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-WNK4 Antibody (aa200-300, DY550) - LS-C142345 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-WNK4 Antibody (aa200-300, HRP) - LS-C142344 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-WNK4 Antibody (aa115-144, AP) - LS-C242756 from LifeSpan Bioscience Prices $435.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-WNK4 Antibody (aa115-144, FITC) - LS-C242757 from LifeSpan Bioscience Prices $435.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-WNK4 Antibody (C-Terminus, AP) - LS-C246406 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-WNK4 Antibody (aa115-144, PE) - LS-C242759 from LifeSpan Bioscience Prices $435.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-WNK4 Antibody (C-Terminus, APC) - LS-C246407 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-WNK4 Antibody (aa115-144, APC) - LS-C242758 from LifeSpan Bioscience Prices $435.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-WNK4 Antibody (C-Terminus, FITC) - LS-C246408 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-WNK4 Antibody (C-Terminus, PE) - LS-C246409 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-WNK4 Antibody (C-Terminus) - LS-C329112 from LifeSpan Bioscience Prices $425.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-WNK4 Antibody (aa115-144) - LS-C330300 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

WNK4 Antibody - NB600-284 from Novus Biologicals Prices $99.00, $299.00 Sizes 25 µl, 100 µl Host Rabbit Clonality Polyclonal

WNK4 Antibody - NBP1-92597 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

WNK4 Antibody [Alexa Fluor (R) 700] - NB600-284AF700 from Novus Biologicals Prices $319.00 Sizes 100 tests Host Rabbit Clonality Polyclonal

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