| Gene Symbol |
WNK4
|
| Entrez Gene |
65266
|
| Alt Symbol |
PHA2B, PRKWNK4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
WNK lysine deficient protein kinase 4
|
| Other Description |
protein kinase lysine-deficient 4|protein kinase with no lysine 4|serine/threonine-protein kinase WNK4
|
| Swissprots |
B0LPI0 Q96J92 Q9BYS5 Q96DT8 Q8N8Z2 Q8N8X3
|
| Accessions |
ABY87559 EAW60881 EAW60882 Q96J92 AF390018 AAK91995 AJ309861 CAC32991 AJ316534 CAC48387 AK096003 BAC04669 AK096052 BAC04688 AK301963 BAG63376 BC136664 AAI36665 BC144356 BM683764 CA388932 XM_005257595 XP_005257652 XM_005257596 XP_005257653 XM_005257597 XP_005257654 XM_006722020 XP_006722083 XM_006722021 XP_006722084 XM_006722022 XP_006722085 XM_011525132 XP_011523434 XM_011525133 XP_011523435 XM_011525134 XP_011523436 XM_011525135 XP_011523437 NM_032387 NP_115763
|
| Function |
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis. Phosphorylates NEDD4L. {ECO:0000269|PubMed:20525693}.
|
| Subcellular Location |
Cell junction, tight junction {ECO:0000250}. Note=Present exclusively in intercellular junctions in the distal convoluted tubule and in both the cytoplasm and intercellular junctions in the cortical collecting duct. WNK4 is part of the tight junction complex (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Expressed in kidney, colon and skin. {ECO:0000269|PubMed:11571656}.
|