WNK4

Gene Symbol	WNK4
Entrez Gene	65266
Alt Symbol	PHA2B, PRKWNK4
Species	Human
Gene Type	protein-coding
Description	WNK lysine deficient protein kinase 4
Other Description	protein kinase lysine-deficient 4|protein kinase with no lysine 4|serine/threonine-protein kinase WNK4
Swissprots	B0LPI0 Q96J92 Q9BYS5 Q96DT8 Q8N8Z2 Q8N8X3
Accessions	ABY87559 EAW60881 EAW60882 Q96J92 AF390018 AAK91995 AJ309861 CAC32991 AJ316534 CAC48387 AK096003 BAC04669 AK096052 BAC04688 AK301963 BAG63376 BC136664 AAI36665 BC144356 BM683764 CA388932 XM_005257595 XP_005257652 XM_005257596 XP_005257653 XM_005257597 XP_005257654 XM_006722020 XP_006722083 XM_006722021 XP_006722084 XM_006722022 XP_006722085 XM_011525132 XP_011523434 XM_011525133 XP_011523435 XM_011525134 XP_011523436 XM_011525135 XP_011523437 NM_032387 NP_115763
Function	Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis. Phosphorylates NEDD4L. {ECO:0000269|PubMed:20525693}.
Subcellular Location	Cell junction, tight junction {ECO:0000250}. Note=Present exclusively in intercellular junctions in the distal convoluted tubule and in both the cytoplasm and intercellular junctions in the cortical collecting duct. WNK4 is part of the tight junction complex (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in kidney, colon and skin. {ECO:0000269|PubMed:11571656}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human WNK4 protein fragment - ab163932 from Abcam Category Protein Source Wheat germ Species Human

WNK4 Peptide - NB600-226PEP from Novus Biologicals Category Peptide Prices $99.00 Sizes 500 µl

Recombinant Human WNK4 Protein - H00065266-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

WNK4 - H00065266-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

WNK4 - H00065266-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

WNK4 - P5665 from Acris Antibodies Category Protein Prices $1,010.00 Sizes 5 µg Species Human

WNK4 fusion protein - Ag17879 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

WNK4 fusion protein - Ag17773 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

WNK4 Peptide - 350572 from ABBIOTEC Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human WNK4, His-tagged - WNK4-3736H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Serine/threonine-protein kinase WNK4(WNK4) ,partial - CSB-YP842690HU CSB-EP842690HU CSB-BP842690HU CSB-MP842690HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Active mouse WNK4 protein fragment - ab206027 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Mouse

WNK4 - TP323269 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

WNK4 Blocking Peptide - NB600-284PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 100 µg Species Human

WNK4 Recombinant Protein Antigen - NBP1-92597PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

WNK4-PRKWNK4-Antibody-N-term-Blocking-peptide - BP7055c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

WNK4-PRKWNK4-Antibody-C-term-Blocking-peptide - BP7055b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

WNK4 Peptide, Human - M34GP17510H from Creative Peptides Category Peptide Source Synthetic. Species Human

Serine/threonine-protein kinase WNK4 (WNK4), partial, Recombinant Protein - MBS1481720 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Recombinant Human WNK4 Protein, MYC/DDK-tagged - WNK4-360H from Creative Biomart Category Protein Source HEK293 Species Human

Recombinant Human WNK4 protein, Flag-tagged, Biotinylated - WNK4-91H from Creative Biomart Category Protein Source Insect cell Species Human

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