LILRB4

Gene Symbol	LILRB4
Entrez Gene	11006
Alt Symbol	CD85K, ILT-3, ILT3, LIR-5, LIR5
Species	Human
Gene Type	protein-coding
Description	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
Other Description	CD85 antigen-like family member K|immunoglobulin-like transcript 3|leukocyte immunoglobulin-like receptor 5|leukocyte immunoglobulin-like receptor subfamily B member 4|monocyte inhibitory receptor HM18
Swissprots	O15468 Q8NHJ6 Q8N1C7 Q6FGQ9 Q8NHL5 O75021 A8MVL8
Accessions	AAC99761 AAG02024 EAW72270 EAW72271 EAW72272 Q8NHJ6 AF025532 AAB87666 AF283988 AAL36992 AK292082 BAF84771 AK309227 AK314783 BC026309 AAH26309 BC032342 BU175229 BX094825 CR542048 CAG46845 DQ892089 ABM83015 DQ895282 ABM86208 EU915607 ACK56073 U82979 AAC51355 U91925 AAB68665 XM_005277282 XP_005277339 XM_011526365 XP_011524667 XM_011526366 XP_011524668 XM_011526367 XP_011524669 XM_011526368 XP_011524670 XM_011547072 XP_011545374 XM_011547073 XP_011545375 XM_011547074 XP_011545376 XM_011547075 XP_011545377 XM_011548525 XP_011546827 XM_011548526 XP_011546828 XM_011548527 XP_011546829 XM_011548528 XP_011546830 XM_011548588 XP_011546890 XM_011548589 XP_011546891 XM_011548590 XP_011546892 XM_011548591 XP_011546893 XM_011548653 XP_011546955 XM_011548654 XP_011546956 XM_011548655 XP_011546957 XM_011548656 XP_011546958 XM_011548657 XP_011546959 XM_011548658 XP_011546960 XM_011548659 XP_011546961 XM_011548660 XP_011546962 NM_001278426 NP_001265355 NM_001278427 NP_001265356 NM_001278428 NP_001265357 NM_001278429 NP_001265358 NM_001278430 NP_001265359 NM_001081438 NM_006847
Function	Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5- signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. {ECO:0000269|PubMed:11875462, ECO:0000269|PubMed:9151699}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:9151699}; Single-pass type I membrane protein {ECO:0000269|PubMed:9151699}. Note=Ligand binding leads to internalization and translocation to an antigen-processing compartment.
Tissue Specificity	Detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells. {ECO:0000269|PubMed:9151699, ECO:0000269|PubMed:9278324, ECO:0000269|PubMed:9548455}.
Top Pathways	Osteoclast differentiation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ILT-3 (H-217) - sc-366213 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

ILT-2/3/5 (C-18) - sc-33453 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

ILT-3/5/8/11 (N-20) - sc-33451 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-LILRB4 antibody - ab129772 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-LILRB4 antibody - N-terminal - ab170669 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-ILT3 / LILRB4 Antibody (clone 293623, APC) - LS-C36876 from LifeSpan Bioscience Prices $545.00 Sizes 100 tst Host Mouse Clonality Monoclonal Clone 293623

Anti-ILT3 / LILRB4 Antibody (Extracellular Domain, clone 293622) - LS-C70529 from LifeSpan Bioscience Prices $465.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 293622

Anti-ILT3 / LILRB4 Antibody (Extracellular Domain, clone 293623) - LS-C70530 from LifeSpan Bioscience Prices $465.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 293623

Anti-ILT3 / LILRB4 Antibody (clone 293623, PE) - LS-C36878 from LifeSpan Bioscience Prices $495.00 Sizes 100 tst Host Mouse Clonality Monoclonal Clone 293623

Anti-ILT3 / LILRB4 Antibody (clone ZM4.1) - LS-C190922 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone ZM4.1

Anti-ILT3 / LILRB4 Antibody (CF) - LS-C36877 from LifeSpan Bioscience Prices $445.00 Sizes 100 tst Host Mouse Clonality Monoclonal

Anti-ILT3 / LILRB4 Antibody (aa43-73, Biotin) - LS-C261903 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ILT3 / LILRB4 Antibody (aa43-73, APC) - LS-C261901 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ILT3 / LILRB4 Antibody (aa43-73, Azide-free, HRP) - LS-C261905 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ILT3 / LILRB4 Antibody (aa43-73, AP) - LS-C261902 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ILT3 / LILRB4 Antibody (aa201-250) - LS-C120063 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ILT3 / LILRB4 Antibody (aa43-73, FITC) - LS-C261904 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ILT3 / LILRB4 Antibody (aa24-206, Biotin) - LS-C298241 from LifeSpan Bioscience Prices $425.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ILT3 / LILRB4 Antibody (aa43-73, PE) - LS-C261907 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ILT3 / LILRB4 Antibody (aa24-206, FITC) - LS-C302400 from LifeSpan Bioscience Prices $445.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ILT3 / LILRB4 Antibody (aa43-73) - LS-C329765 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ILT3 / LILRB4 Antibody (aa24-206) - LS-C295154 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ILT3 / LILRB4 Antibody (aa44-73) - LS-C165771 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

ILT3/CD85k/LILRB4 Antibody (293623) [Unconjugated] - MAB24251 from Novus Biologicals Prices $99.00, $259.00 Sizes 25 µg, 100 µg Host Mouse Clonality Monoclonal Clone 293623

ILT3/CD85k/LILRB4 Antibody [Unconjugated] - AF2425 from Novus Biologicals Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Goat Clonality Polyclonal

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