LILRB4

Gene Symbol LILRB4
Entrez Gene 11006
Alt Symbol CD85K, ILT-3, ILT3, LIR-5, LIR5
Species Human
Gene Type protein-coding
Description leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
Other Description CD85 antigen-like family member K|immunoglobulin-like transcript 3|leukocyte immunoglobulin-like receptor 5|leukocyte immunoglobulin-like receptor subfamily B member 4|monocyte inhibitory receptor HM18
Swissprots O15468 Q8NHJ6 Q8N1C7 Q6FGQ9 Q8NHL5 O75021 A8MVL8
Accessions AAC99761 AAG02024 EAW72270 EAW72271 EAW72272 Q8NHJ6 AF025532 AAB87666 AF283988 AAL36992 AK292082 BAF84771 AK309227 AK314783 BC026309 AAH26309 BC032342 BU175229 BX094825 CR542048 CAG46845 DQ892089 ABM83015 DQ895282 ABM86208 EU915607 ACK56073 U82979 AAC51355 U91925 AAB68665 XM_005277282 XP_005277339 XM_011526365 XP_011524667 XM_011526366 XP_011524668 XM_011526367 XP_011524669 XM_011526368 XP_011524670 XM_011547072 XP_011545374 XM_011547073 XP_011545375 XM_011547074 XP_011545376 XM_011547075 XP_011545377 XM_011548525 XP_011546827 XM_011548526 XP_011546828 XM_011548527 XP_011546829 XM_011548528 XP_011546830 XM_011548588 XP_011546890 XM_011548589 XP_011546891 XM_011548590 XP_011546892 XM_011548591 XP_011546893 XM_011548653 XP_011546955 XM_011548654 XP_011546956 XM_011548655 XP_011546957 XM_011548656 XP_011546958 XM_011548657 XP_011546959 XM_011548658 XP_011546960 XM_011548659 XP_011546961 XM_011548660 XP_011546962 NM_001278426 NP_001265355 NM_001278427 NP_001265356 NM_001278428 NP_001265357 NM_001278429 NP_001265358 NM_001278430 NP_001265359 NM_001081438 NM_006847
Function Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5- signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. {ECO:0000269|PubMed:11875462, ECO:0000269|PubMed:9151699}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:9151699}; Single-pass type I membrane protein {ECO:0000269|PubMed:9151699}. Note=Ligand binding leads to internalization and translocation to an antigen-processing compartment.
Tissue Specificity Detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells. {ECO:0000269|PubMed:9151699, ECO:0000269|PubMed:9278324, ECO:0000269|PubMed:9548455}.
Top Pathways Osteoclast differentiation

ILT-3 CRISPR/Cas9 KO Plasmid (h) - sc-407764 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ILT-3 HDR Plasmid (h) - sc-407764-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ILT-3 Double Nickase Plasmid (h) - sc-407764-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ILT-3 Double Nickase Plasmid (h2) - sc-407764-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ILT-3 CRISPR Activation Plasmid (h) - sc-407764-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ILT-3 CRISPR Activation Plasmid (h2) - sc-407764-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ILT-3 Lentiviral Activation Particles (h) - sc-407764-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ILT-3 Lentiviral Activation Particles (h2) - sc-407764-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ILT-3 siRNA (h) - sc-44997 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ILT-3 shRNA Plasmid (h) - sc-44997-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ILT-3 shRNA (h) Lentiviral Particles - sc-44997-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ILT3/CD85k/LILRB4 RNAi - H00011006-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU029201 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN11715 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11715 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02914 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr02914

LILRB4 siRNA (Human) - CRH7516 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human LILRB4 (NM_006847.3) - SHH330315 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human LILRB4(NM_006847.3) - SHH149717 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human LILRB4(NM_001081438.1) - SHH149735 from Creative biogene

Category siRNA
Species Reactivities Human

LILRB4 shRNA Plasmid (Human) - CHH7516 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

LILRB4 miRNA 3'UTR clone - MiUTR1H-05678 from Creative biogene

Species Reactivities Human

LILRB4 miRNA 3'UTR clone - MiUTR1H-05679 from Creative biogene

Species Reactivities Human
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