LILRB4

Gene Symbol	LILRB4
Entrez Gene	11006
Alt Symbol	CD85K, ILT-3, ILT3, LIR-5, LIR5
Species	Human
Gene Type	protein-coding
Description	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
Other Description	CD85 antigen-like family member K|immunoglobulin-like transcript 3|leukocyte immunoglobulin-like receptor 5|leukocyte immunoglobulin-like receptor subfamily B member 4|monocyte inhibitory receptor HM18
Swissprots	O15468 Q8NHJ6 Q8N1C7 Q6FGQ9 Q8NHL5 O75021 A8MVL8
Accessions	AAC99761 AAG02024 EAW72270 EAW72271 EAW72272 Q8NHJ6 AF025532 AAB87666 AF283988 AAL36992 AK292082 BAF84771 AK309227 AK314783 BC026309 AAH26309 BC032342 BU175229 BX094825 CR542048 CAG46845 DQ892089 ABM83015 DQ895282 ABM86208 EU915607 ACK56073 U82979 AAC51355 U91925 AAB68665 XM_005277282 XP_005277339 XM_011526365 XP_011524667 XM_011526366 XP_011524668 XM_011526367 XP_011524669 XM_011526368 XP_011524670 XM_011547072 XP_011545374 XM_011547073 XP_011545375 XM_011547074 XP_011545376 XM_011547075 XP_011545377 XM_011548525 XP_011546827 XM_011548526 XP_011546828 XM_011548527 XP_011546829 XM_011548528 XP_011546830 XM_011548588 XP_011546890 XM_011548589 XP_011546891 XM_011548590 XP_011546892 XM_011548591 XP_011546893 XM_011548653 XP_011546955 XM_011548654 XP_011546956 XM_011548655 XP_011546957 XM_011548656 XP_011546958 XM_011548657 XP_011546959 XM_011548658 XP_011546960 XM_011548659 XP_011546961 XM_011548660 XP_011546962 NM_001278426 NP_001265355 NM_001278427 NP_001265356 NM_001278428 NP_001265357 NM_001278429 NP_001265358 NM_001278430 NP_001265359 NM_001081438 NM_006847
Function	Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5- signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. {ECO:0000269|PubMed:11875462, ECO:0000269|PubMed:9151699}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:9151699}; Single-pass type I membrane protein {ECO:0000269|PubMed:9151699}. Note=Ligand binding leads to internalization and translocation to an antigen-processing compartment.
Tissue Specificity	Detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells. {ECO:0000269|PubMed:9151699, ECO:0000269|PubMed:9278324, ECO:0000269|PubMed:9548455}.
Top Pathways	Osteoclast differentiation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human LILRB4 full length protein - ab161237 from Abcam Category Protein Source Wheat germ Species Human

Human LILRB4 protein fragment - ab179985 from Abcam Category Protein Source HEK 293 cells Species Human

ILT3 / LILRB4 Antibody Blocking Peptide - LS-E1557 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ILT3/CD85k/LILRB4 Recombinant Protein - H00011006-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

LILRB4-Antibody-N-term-Blocking-peptide - BP12297a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human LILRB4/CD85k/ILT3, CF - 8488-T4-025 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Pro17-His257, with a C-terminal 6-His tag

CD85k / LILRB4 - H00011006-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

LILRB4 Recombinant Protein - 96-517 from ProSci Category Protein Source HEK293 cells Species Human

LILRB4 Recombinant Protein - 96-518 from ProSci Category Protein Prices $500.00 Sizes 50 µg Source HEK293 cells Species Human

LILRB4 fusion protein - Ag3219 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, T-HIS Species Human

Recombinant Human LILRB4, His-tagged - LILRB4-582H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human LILRB4 - LILRB4-721H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Human LILRB4, His-tagged - LILRB4-318H from Creative Biomart Category Protein Source NSO cells Species Human

Recombinant Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) - RPB399Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Human LILRB4 / CD85k / ILT3 Protein - LI4-H5229 from ACROBiosystems Category Protein Source Recombinant Human LILRB4 /CD85K Protein (rh LILRB4 / ILT3 /CD85k) Gln 22 - Glu 259 (Accession # AAH26309) was produced in human 293 cells (HEK293) at ACROBiosystems. Species Human

Human LILRB4 / CD85k / ILT3 Protein, Fc Tag - LI4-H5259 from ACROBiosystems Category Protein Prices $350.00, $2,200.00 Sizes 50 µg, 1 mg Source Human LILRB4, Fc Tag (LI4-H5259) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - Glu 259 (Accession # AAH26309). Species Human

Recombinant Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) - RPB399Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Leukocyte immunoglobulin-like receptor subfamily B member 4(LI - CSB-YP850914HU CSB-EP850914HU CSB-BP850914HU CSB-MP850914HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human LILRB4/CD85k/ILT3 Protein, CF - 8488-T4 from R&D Systems Category Protein Prices $329.00 Sizes 25 µg Source Mouse myeloma cell line, NS0-derived Pro17-His257, with a C-terminal 6-His tag Species Human

LILRB4 Protein - abx164037 from Abbexa Category Protein Species Human, Mouse

Human LILRB4 / CD85k / ILT3 Protein (His Tag) - PKSH030439 from Elabscience Category Protein Source Human Cells Species Human

Human LILRB4 protein - orb257671 from Biorbyt Category Protein Prices $544.00, $3,060.00 Sizes 50 μg, 1 mg Species Human

Recombinant Human LILRB4 protein, Fc-tagged - LILRB4-14H from Creative Biomart Category Protein Source HEK293 Species Human

Recombinant Human LILRB4 protein, GST-tagged - LILRB4-146H from Creative Biomart Category Protein Source Wheat Germ Species Human

Recombinant Human LILRB4 protein, His-tagged - LILRB4-15H from Creative Biomart Category Protein Source HEK293 Species Human

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