PLAG1

Gene Symbol	PLAG1
Entrez Gene	5324
Alt Symbol	PSA, SGPA, ZNF912
Species	Human
Gene Type	protein-coding
Description	pleiomorphic adenoma gene 1
Other Description	COL1A2/PLAG1 fusion|zinc finger protein PLAG1
Swissprots	Q9Y4L2 B4DLC2 Q59GH8 Q6DJT9
Accessions	CAB42491 EAW86774 EAW86775 Q6DJT9 AB209131 BAD92368 AF221549 AF221550 AK296933 BAG59484 AK313663 BAG36415 BC075047 AAH75047 BC075048 AAH75048 DA225321 DC347559 EF525168 EF525169 EF525170 ABW87255 EU446900 ABZ92429 U65002 AAC50995 U78783 XM_005251260 XP_005251317 XM_011517544 XP_011515846 NM_001114634 NP_001108106 NM_001114635 NP_001108107 NM_002655 NP_002646
Function	Transcription factor whose activation results in up- regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia. {ECO:0000269|PubMed:11888928, ECO:0000269|PubMed:14695992, ECO:0000269|PubMed:14712223}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:10646861, ECO:0000269|PubMed:11882654, ECO:0000269|PubMed:16207715}. Note=Strong nucleolar localization when sumoylation is inhibited.
Tissue Specificity	Expressed in fetal tissues such as lung, liver and kidney. Not detected or weak detection in normal adult tissues, but highly expressed in salivary gland with benign or malignant pleiomorphic adenomas with or without 8q12 aberrations, with preferential occurrence in benign tumors. {ECO:0000269|PubMed:10029085, ECO:0000269|PubMed:14695992, ECO:0000269|PubMed:9020842, ECO:0000269|PubMed:9722527}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PLAG1 protein fragment - ab116786 from Abcam Category Protein Source Wheat germ Species Human

PLAG1 Antibody Blocking Peptide - LS-E1125 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PLAG1 Antibody Blocking Peptide - LS-E13714 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PLAG1 Antibody Blocking Peptide - LS-E13713 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PLAG1 Protein - H00005324-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PLAG1-Antibody-N-term-Blocking-peptide - BP11647a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PLAG1 - H00005324-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PLAG1 - H00005324-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PLAG1 fusion protein - ag12566 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human PLAG1 - PLAG1-31026TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human PLAG1, His-tagged - PLAG1-1762H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Zinc finger protein PLAG1(PLAG1) - CSB-YP718773HU CSB-EP718773HU CSB-BP718773HU CSB-MP718773HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Zinc finger protein PLAG1 (PLAG1) , Recombinant Protein - MBS1296874 from MyBioSource Category Protein Prices $2,110.00, $2,110.00, $2,575.00, $2,575.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

PLAG1 Peptide, Human - M34GP11887H from Creative Peptides Category Peptide Source Synthetic. Species Human

PLAG1 Recombinant Protein Antigen - NBP2-56656PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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