Gene Symbol | CACNG3 |
---|---|
Entrez Gene | 10368 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | calcium channel, voltage-dependent, gamma subunit 3 |
Other Description | TARP gamma-3|neuronal voltage-gated calcium channel gamma-3 subunit|transmembrane AMPAR regulatory protein gamma-3|voltage-dependent calcium channel gamma-3 subunit|voltage-gated calcium channel gamma subunit |
Swissprots | O60359 |
Accessions | AAC15246 EAW55793 EAW55794 O60359 AF100346 AAD22739 AF114832 AAP97231 AF134640 AAF42975 AK055453 BAG51520 AK095553 BAG53082 AK315150 BAG37598 BC033741 BC037899 AAH37899 BC040005 AAH40005 H04803 HQ447969 ADQ32452 NM_006539 NP_006530 |
Function | Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity). {ECO:0000250}. |
Subcellular Location | Membrane; Multi-pass membrane protein. |
Top Pathways | MAPK signaling pathway, Cardiac muscle contraction, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy |