Gene Symbol | CACNG3 |
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Entrez Gene | 10368 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | calcium channel, voltage-dependent, gamma subunit 3 |
Other Description | TARP gamma-3|neuronal voltage-gated calcium channel gamma-3 subunit|transmembrane AMPAR regulatory protein gamma-3|voltage-dependent calcium channel gamma-3 subunit|voltage-gated calcium channel gamma subunit |
Swissprots | O60359 |
Accessions | AAC15246 EAW55793 EAW55794 O60359 AF100346 AAD22739 AF114832 AAP97231 AF134640 AAF42975 AK055453 BAG51520 AK095553 BAG53082 AK315150 BAG37598 BC033741 BC037899 AAH37899 BC040005 AAH40005 H04803 HQ447969 ADQ32452 NM_006539 NP_006530 |
Function | Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity). {ECO:0000250}. |
Subcellular Location | Membrane; Multi-pass membrane protein. |
Top Pathways | MAPK signaling pathway, Cardiac muscle contraction, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy |
L-type Ca ++ CP γ3 CRISPR/Cas9 KO Plasmid (h) - sc-406760 from Santa Cruz Biotechnology
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L-type Ca ++ CP γ3 HDR Plasmid (h) - sc-406760-HDR from Santa Cruz Biotechnology
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L-type Ca ++ CP γ3 Double Nickase Plasmid (h) - sc-406760-NIC from Santa Cruz Biotechnology
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L-type Ca ++ CP γ3 Double Nickase Plasmid (h2) - sc-406760-NIC-2 from Santa Cruz Biotechnology
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L-type Ca ++ CP γ3 CRISPR Activation Plasmid (h) - sc-406760-ACT from Santa Cruz Biotechnology
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L-type Ca ++ CP γ3 CRISPR Activation Plasmid (h2) - sc-406760-ACT-2 from Santa Cruz Biotechnology
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L-type Ca ++ CP γ3 Lentiviral Activation Particles (h) - sc-406760-LAC from Santa Cruz Biotechnology
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L-type Ca ++ CP γ3 Lentiviral Activation Particles (h2) - sc-406760-LAC-2 from Santa Cruz Biotechnology
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L-type Ca ++ CP γ3 siRNA (h) - sc-93047 from Santa Cruz Biotechnology
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L-type Ca ++ CP γ3 shRNA Plasmid (h) - sc-93047-SH from Santa Cruz Biotechnology
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L-type Ca ++ CP γ3 shRNA (h) Lentiviral Particles - sc-93047-V from Santa Cruz Biotechnology
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CACNG3 RNAi - H00010368-R01 from Novus Biologicals
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MISSION® esiRNA - EHU150711 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5275 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5275 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04144 from Sigma-Aldrich
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CACNG3 siRNA (Human) - CRH7025 from Cohesion Biosciences
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CACNG3 - MBS8201386 from MyBioSource
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L-type Ca++ CP γ3 CRISPR/Cas9 KO Plasmid (h2) - sc-406760-KO-2 from Santa Cruz Biotechnology
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L-type Ca++ CP γ3 HDR Plasmid (h2) - sc-406760-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human CACNG3 (NM_006539.3) - SHH253489 from Creative biogene
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CACNG3 shRNA Plasmid (Human) - CHH7025 from Cohesion Biosciences
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CACNG3 miRNA 3'UTR clone - MiUTR3H-08426 from Creative biogene
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