PTPRJ

Gene Symbol	PTPRJ
Entrez Gene	5795
Alt Symbol	CD148, DEP1, HPTPeta, R-PTP-ETA, SCC1
Species	Human
Gene Type	protein-coding
Description	protein tyrosine phosphatase, receptor type, J
Other Description	CD148 antigen|DEP-1|HPTP eta|R-PTP-J|density-enhanced phosphatase 1|human density enhanced phosphatase-1|protein tyrosine phosphatase, receptor type, J polypeptide|protein-tyrosine phosphatase eta|protein-tyrosine phosphatase receptor type J|receptor-type tyrosine-protein phosphatase eta|susceptibility to colon cancer 1, mouse, homolog of
Swissprots	Q6P4H4 Q8NHM2 Q15255 Q12913 Q9UDA9
Accessions	EAW67873 EAW67874 EAW67875 EAW67876 Q12913 AI218139 AL359057 CAB94390 AL832403 BC019824 BC063417 AAH63417 BC098447 BC160125 AAI60125 D37781 BAA07035 DR007037 U10886 AAB36687 XM_011520249 XP_011518551 XR_930883 NM_001098503 NP_001091973 NM_002843 NP_002834
Function	Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immu
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane {ECO:0000250}. Cell junction. Note=After T-cell stimulation, it is temporarily excluded from immunological synapses.
Tissue Specificity	Expressed in the promyelocytic cell line HL- 60, the granulocyte-macrophage colony-stimulating factor-dependent leukemic cell line F-36P, and the IL3 and erythropoietin-dependent leukemic cell line F-36E. Expressed predominantly in epithelial cells and lymphocytes. Enhanced expression at high cell density. {ECO:0000269|PubMed:12370829, ECO:0000269|PubMed:8483328, ECO:0000269|PubMed:9531590}.
Top Pathways	Adherens junction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PTPRJ / CD148 ELISA Kit (Sandwich ELISA) - LS-F9242 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 0.117 ng/ml Range 0.313-20 ng/ml

Protein Tyrosine Phosphatase Receptor Type J (PTPRJ), Human, ELISA Kit - SEB545Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 0.117ng/mL Range 0.312-20ng/mL

Receptor-type tyrosine-protein phosphatase eta (PTPRJ), Human, ELISA Kit - E01R0375 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Receptor-type tyrosine-protein phosphatase eta (PTPRJ), ELISA Kit - MBS7247149 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Receptor-type tyrosine-protein phosphatase eta (PTPRJ), ELISA Kit - MBS7239482 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Receptor-type tyrosine-protein phosphatase eta (PTPRJ), ELISA Kit - MBS7252803 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Receptor-type tyrosine-protein phosphatase eta (PTPRJ), ELISA Kit - MBS7245398 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Receptor-type tyrosine-protein phosphatase eta (PTPRJ), ELISA Kit - MBS7213928 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Receptor-type tyrosine-protein phosphatase eta (PTPRJ), ELISA Kit - MBS7222888 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Receptor-type tyrosine-protein phosphatase eta (PTPRJ), ELISA Kit - MBS7225709 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Receptor-type tyrosine-protein phosphatase eta (PTPRJ), ELISA Kit - MBS7248265 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Receptor-type tyrosine-protein phosphatase eta (PTPRJ), ELISA Kit - MBS7214510 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

protein tyrosine phosphatase, receptor type, J, ELISA Kit - MBS9339313 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Receptor type tyrosine protein phosphatase eta (PTPRJ), ELISA Kit - MBS7235902 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) - SEB545Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.117ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) - SEB545Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.117ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Receptor-type tyrosine-protein phosphatase eta (PTPRJ), ELISA Kit - MBS7237666 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human PTPRJ ELISA Kit - abx152897 from Abbexa Category ELISA Kit Sensitivity 0.117 ng/ml Range 0.313 ng/ml - 20 ng/ml

Custom Human DEP-1 ELISA - ELH-DEP1 from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human PTPRJ / CD148 ELISA Kit (Sandwich ELISA) - LS-F22052 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 0.31 ng/ml Range 0.313-20 ng/ml

Protein Tyrosine Phosphatase Receptor Type J (PTPRJ), Human, ELISA Kit - DL-PTPRJ-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.312-20 ng/mL

Human DEP-1 ELISA Kit - orb319932 from Biorbyt Category ELISA Kit Prices $1,148.00, $1,981.00, $4,284.00 Sizes 96 assays, 192 assays, 480 assays

Human PTPRJ ELISA Kit - abx573074 from Abbexa Category ELISA Kit Sensitivity 0.117 ng/ml Range 0.313 ng/ml - 20 ng/ml

Human DEP-1 ELISA - RAB1414 from Sigma-Aldrich Prices $615.00 Sizes 1 kt

PTPRJ - EKH7366 from Nordic BioSite Sensitivity 0.188ng/ml Range 0.313--20ng/ml

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