PTPRJ

Gene Symbol	PTPRJ
Entrez Gene	5795
Alt Symbol	CD148, DEP1, HPTPeta, R-PTP-ETA, SCC1
Species	Human
Gene Type	protein-coding
Description	protein tyrosine phosphatase, receptor type, J
Other Description	CD148 antigen|DEP-1|HPTP eta|R-PTP-J|density-enhanced phosphatase 1|human density enhanced phosphatase-1|protein tyrosine phosphatase, receptor type, J polypeptide|protein-tyrosine phosphatase eta|protein-tyrosine phosphatase receptor type J|receptor-type tyrosine-protein phosphatase eta|susceptibility to colon cancer 1, mouse, homolog of
Swissprots	Q6P4H4 Q8NHM2 Q15255 Q12913 Q9UDA9
Accessions	EAW67873 EAW67874 EAW67875 EAW67876 Q12913 AI218139 AL359057 CAB94390 AL832403 BC019824 BC063417 AAH63417 BC098447 BC160125 AAI60125 D37781 BAA07035 DR007037 U10886 AAB36687 XM_011520249 XP_011518551 XR_930883 NM_001098503 NP_001091973 NM_002843 NP_002834
Function	Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immu
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane {ECO:0000250}. Cell junction. Note=After T-cell stimulation, it is temporarily excluded from immunological synapses.
Tissue Specificity	Expressed in the promyelocytic cell line HL- 60, the granulocyte-macrophage colony-stimulating factor-dependent leukemic cell line F-36P, and the IL3 and erythropoietin-dependent leukemic cell line F-36E. Expressed predominantly in epithelial cells and lymphocytes. Enhanced expression at high cell density. {ECO:0000269|PubMed:12370829, ECO:0000269|PubMed:8483328, ECO:0000269|PubMed:9531590}.
Top Pathways	Adherens junction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human DEP1 protein fragment - ab42588 from Abcam Category Protein Prices $284.00 Sizes 20 µg Source E. coli Species Human

DEP-1/CD148 Partial Recombinant Protein - H00005795-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human DEP-1/CD148 (aa 997-1337), CF - 1934-DP-010 from R&D Systems Category Protein Source E. coli-derived, Arg997-Ala1337, with an N-terminal Met & 6-His tag

Human PTPRJ Protein - abx068775 from Abbexa Category Protein Source E.coli Species Human

CD148 / PTPRJ - H00005795-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CD148 / PTPRJ - H00005795-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

DEP1(PTPRJ), Active Human Recombinant Protein - GWB-PSF58A from Genway Biotech Category Protein Prices $353.00 Sizes 20 µg Species Human

Recombinant Human PTPRJ - PTPRJ-28068TH from Creative Biomart Category Protein Source E. coli

Recombinant Human PTPRJ, GST-tagged - PTPRJ-206H from Creative Biomart Category Protein Source E. coli

Recombinant Human Protein Tyrosine Phosphatase, Receptor Type, J - PTPRJ-205H from Creative Biomart Category Protein Source E.coli.

Recombinant Human PTPRJ(1024-1306), GST-tagged - PTPRJ-507H from Creative Biomart Category Protein Source E.coli.

Recombinant Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) - RPB545Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) - RPB545Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) - RPB545Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Human DEP1 / PTPRJ Protein (aa 997-1337, His Tag) - 13165-H07E-10 from Sino Biological Category Protein Source E. coli Species Human

Recombinant Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) - RPB545Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Receptor-type tyrosine-protein phosphatase eta(PTPRJ) ,partial - CSB-YP613274HU CSB-EP613274HU CSB-BP613274HU CSB-MP613274HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human DEP-1/CD148 (aa 997-1337) Protein, CF - 1934-DP from R&D Systems Category Protein Prices $329.00 Sizes 10 µg Source E. coli -derived Arg997-Ala1337, with an N-terminal Met & 6-His tag Species Human

CD148 / PTPRJ (transcript variant 1) - TP322707 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Recombinant Human PTPRJ Active - PTP050A from Cell Science Prices $399.00 Sizes 20 μg Species Human

Human PTPRJ protein (His Tag) - orb139555 from Biorbyt Category Protein Prices $510.00, $748.00 Sizes 10 μg, 20 μg Source E. coli Species Human

Recombinant Human PTPRJ Protein, His-tagged - PTPRJ-498H from Creative Biomart Category Protein Source E. coli Species Human

DEP-1/CD148 Recombinant Protein Antigen - NBP1-86547PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

DEP1-Antibody-C-term-Blocking-Peptide - BP8402a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PTPRJ Peptide, Human - M34GP12721H from Creative Peptides Category Peptide Source Synthetic. Species Human

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