| Gene Symbol | PTPRJ |
|---|---|
| Entrez Gene | 5795 |
| Alt Symbol | CD148, DEP1, HPTPeta, R-PTP-ETA, SCC1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein tyrosine phosphatase, receptor type, J |
| Other Description | CD148 antigen|DEP-1|HPTP eta|R-PTP-J|density-enhanced phosphatase 1|human density enhanced phosphatase-1|protein tyrosine phosphatase, receptor type, J polypeptide|protein-tyrosine phosphatase eta|protein-tyrosine phosphatase receptor type J|receptor-type tyrosine-protein phosphatase eta|susceptibility to colon cancer 1, mouse, homolog of |
| Swissprots | Q6P4H4 Q8NHM2 Q15255 Q12913 Q9UDA9 |
| Accessions | EAW67873 EAW67874 EAW67875 EAW67876 Q12913 AI218139 AL359057 CAB94390 AL832403 BC019824 BC063417 AAH63417 BC098447 BC160125 AAI60125 D37781 BAA07035 DR007037 U10886 AAB36687 XM_011520249 XP_011518551 XR_930883 NM_001098503 NP_001091973 NM_002843 NP_002834 |
| Function | Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immu |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane {ECO:0000250}. Cell junction. Note=After T-cell stimulation, it is temporarily excluded from immunological synapses. |
| Tissue Specificity | Expressed in the promyelocytic cell line HL- 60, the granulocyte-macrophage colony-stimulating factor-dependent leukemic cell line F-36P, and the IL3 and erythropoietin-dependent leukemic cell line F-36E. Expressed predominantly in epithelial cells and lymphocytes. Enhanced expression at high cell density. {ECO:0000269|PubMed:12370829, ECO:0000269|PubMed:8483328, ECO:0000269|PubMed:9531590}. |
| Top Pathways | Adherens junction |