ITPA

Gene Symbol	ITPA
Entrez Gene	3704
Alt Symbol	C20orf37, HLC14-06-P, My049, dJ794I6.3
Species	Human
Gene Type	protein-coding
Description	inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
Other Description	ITPase|NTPase|inosine triphosphatase-A|inosine triphosphate pyrophosphatase|inosine triphosphate pyrophosphohydrolase|non-canonical purine NTP pyrophosphatase|non-standard purine NTP pyrophosphatase|nucleoside-triphosphate diphosphatase|putative oncogene protein HLC14-06-P
Swissprots	A2A2N2 A4UIM5 O14878 B2BCH7 Q9BYN1 Q9BY32 Q9BYX0 Q5JWH4 Q9H3H8
Accessions	BAD81025 EAX10540 EAX10541 EAX10542 Q9BY32 AB062127 BAB93459 AF026816 AAB82608 AF063607 AAG43165 AF219116 AAK21848 AF334680 AAL57168 AK309165 AV694278 BC010138 AAH10138 BF969192 BI115811 BM560812 BQ049090 CA425905 DQ896125 ABM87124 EF199841 ABP01354 EF213026 ABO70316 EU176384 ABW03835 XM_006723564 XP_006723627 XM_006723565 XP_006723628 XM_011529234 XP_011527536 XM_011529235 XP_011527537 NM_001267623 NP_001254552 NM_033453 NP_258412 NM_181493 NP_852470 NR_052000 NR_052001 NR_052002
Function	Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. {ECO:0000255|HAMAP-Rule:MF_03148, ECO:0000269|PubMed:17090528}.
Subcellular Location	Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03148, ECO:0000269|PubMed:11278832}.
Tissue Specificity	Ubiquitous. Highly expressed in heart, liver, sex glands, thyroid and adrenal gland.
Top Pathways	Purine metabolism, Drug metabolism - other enzymes, Pyrimidine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ITPase (A-4) - sc-514409 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

ITPase (C-20) - sc-87779 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

ITPase (FL-194) - sc-367048 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

ITPase (P-18) - sc-87781 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti- Inosine triphosphate pyrophosphatase antibody - ab79967 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti- Inosine triphosphate pyrophosphatase antibody - ab118236 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Inosine triphosphate pyrophosphatase antibody [EPR8779] - ab150420 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR8779

Anti-Inosine triphosphate pyrophosphatase antibody [EPR8780] - ab134937 from Abcam Prices $313.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR8780

Anti-ITPA Antibody (aa30-60) - LS-C322307 from LifeSpan Bioscience Prices $435.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ITPA Antibody (Internal, clone EPR8780) - LS-C154711 from LifeSpan Bioscience Prices $395.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR8780

Anti-ITPA Antibody - LS-C192483 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ITPA Antibody (aa21-177) - LS-C178683 from LifeSpan Bioscience Prices $255.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ITPA Antibody - LS-C331363 from LifeSpan Bioscience Prices $255.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-ITPA Antibody (aa24-51) - LS-C165338 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-ITPA Antibody (aa149-178, AP) - LS-C260563 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ITPA Antibody (aa149-178, APC) - LS-C260564 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ITPA Antibody (aa149-178, Biotin) - LS-C260565 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ITPA Antibody (aa149-178, FITC) - LS-C260566 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ITPA Antibody (aa149-178, Azide-free, HRP) - LS-C260567 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ITPA Antibody (aa149-178, PE) - LS-C260568 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ITPA Antibody (aa24-51, AP) - LS-C260569 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ITPA Antibody (aa24-51, APC) - LS-C260570 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ITPA Antibody (aa24-51, Biotin) - LS-C260571 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ITPA Antibody (aa24-51, FITC) - LS-C260572 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ITPA Antibody (clone 2H8) - LS-C197561 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2H8

Search more