ITPA

Gene Symbol	ITPA
Entrez Gene	3704
Alt Symbol	C20orf37, HLC14-06-P, My049, dJ794I6.3
Species	Human
Gene Type	protein-coding
Description	inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
Other Description	ITPase|NTPase|inosine triphosphatase-A|inosine triphosphate pyrophosphatase|inosine triphosphate pyrophosphohydrolase|non-canonical purine NTP pyrophosphatase|non-standard purine NTP pyrophosphatase|nucleoside-triphosphate diphosphatase|putative oncogene protein HLC14-06-P
Swissprots	A2A2N2 A4UIM5 O14878 B2BCH7 Q9BYN1 Q9BY32 Q9BYX0 Q5JWH4 Q9H3H8
Accessions	BAD81025 EAX10540 EAX10541 EAX10542 Q9BY32 AB062127 BAB93459 AF026816 AAB82608 AF063607 AAG43165 AF219116 AAK21848 AF334680 AAL57168 AK309165 AV694278 BC010138 AAH10138 BF969192 BI115811 BM560812 BQ049090 CA425905 DQ896125 ABM87124 EF199841 ABP01354 EF213026 ABO70316 EU176384 ABW03835 XM_006723564 XP_006723627 XM_006723565 XP_006723628 XM_011529234 XP_011527536 XM_011529235 XP_011527537 NM_001267623 NP_001254552 NM_033453 NP_258412 NM_181493 NP_852470 NR_052000 NR_052001 NR_052002
Function	Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. {ECO:0000255|HAMAP-Rule:MF_03148, ECO:0000269|PubMed:17090528}.
Subcellular Location	Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03148, ECO:0000269|PubMed:11278832}.
Tissue Specificity	Ubiquitous. Highly expressed in heart, liver, sex glands, thyroid and adrenal gland.
Top Pathways	Purine metabolism, Drug metabolism - other enzymes, Pyrimidine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Inosine triphosphate pyrophosphatase full length protein - ab123470 from Abcam Category Protein Source E. coli Species Human

Human Inosine triphosphate pyrophosphatase peptide - ab91608 from Abcam Category Peptide

ITPA Antibody Blocking Peptide - LS-E7657 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ITPA Antibody Blocking Peptide - LS-E6277 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ITPA Partial Recombinant Protein - H00003704-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

ITPA Recombinant Protein - H00003704-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

ITPA Protein - NBP1-45292 from Novus Biologicals Category Protein Species Human

ITPA-Antibody-C-term-Blocking-Peptide - BP18963b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ITPA-Antibody-N-term-Blocking-Peptide - BP4942a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ITPA Protein (OPPA02321) - OPPA02321 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg

Human ITPA protein - orb49446 from Biorbyt Category Protein Prices $408.00, $595.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Human ITPA protein - orb90153 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli Species Human

ITPA protein (His tag) - 80R-1401 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

ITPA (1-194, His-tag) - AR09576PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

ITPA (1-194, His-tag) - AR09576PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

ITPA - H00003704-P01-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

ITPA - H00003704-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ITPA - H00003704-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Inosine Triphosphate Pyrophosphatase, ITPase, Human, Recombinant - 19-CE23 from ARP American Research Products Category Protein Prices $169.00 Sizes 10 µg Source E. coli Species Human

ITPA, 1-194aa, Human, His tag, E.coli - 01-1890 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

ITPA fusion protein - Ag9128 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

ITPA fusion protein - Ag9262 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

ITPA Human - ENPS-556 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human ITPA Enzyme - BP000773-CE23 from Syd Labs Category Protein Prices $180.00, $528.00, $2,640.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli-derived. Species Human

Recombinant Human ITPA Enzyme - BP000773-ENZ-549 from Syd Labs Category Protein Prices $160.00, $2,700.00 Sizes 20 µg, 1 mg Source E. coli-derived. Species Human

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