ITPA

Gene Symbol ITPA
Entrez Gene 3704
Alt Symbol C20orf37, HLC14-06-P, My049, dJ794I6.3
Species Human
Gene Type protein-coding
Description inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
Other Description ITPase|NTPase|inosine triphosphatase-A|inosine triphosphate pyrophosphatase|inosine triphosphate pyrophosphohydrolase|non-canonical purine NTP pyrophosphatase|non-standard purine NTP pyrophosphatase|nucleoside-triphosphate diphosphatase|putative oncogene protein HLC14-06-P
Swissprots A2A2N2 A4UIM5 O14878 B2BCH7 Q9BYN1 Q9BY32 Q9BYX0 Q5JWH4 Q9H3H8
Accessions BAD81025 EAX10540 EAX10541 EAX10542 Q9BY32 AB062127 BAB93459 AF026816 AAB82608 AF063607 AAG43165 AF219116 AAK21848 AF334680 AAL57168 AK309165 AV694278 BC010138 AAH10138 BF969192 BI115811 BM560812 BQ049090 CA425905 DQ896125 ABM87124 EF199841 ABP01354 EF213026 ABO70316 EU176384 ABW03835 XM_006723564 XP_006723627 XM_006723565 XP_006723628 XM_011529234 XP_011527536 XM_011529235 XP_011527537 NM_001267623 NP_001254552 NM_033453 NP_258412 NM_181493 NP_852470 NR_052000 NR_052001 NR_052002
Function Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. {ECO:0000255|HAMAP-Rule:MF_03148, ECO:0000269|PubMed:17090528}.
Subcellular Location Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03148, ECO:0000269|PubMed:11278832}.
Tissue Specificity Ubiquitous. Highly expressed in heart, liver, sex glands, thyroid and adrenal gland.
Top Pathways Purine metabolism, Drug metabolism - other enzymes, Pyrimidine metabolism

ITPase CRISPR/Cas9 KO Plasmid (h) - sc-410841 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ITPase HDR Plasmid (h) - sc-410841-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ITPase Double Nickase Plasmid (h) - sc-410841-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ITPase Double Nickase Plasmid (h2) - sc-410841-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ITPase CRISPR Activation Plasmid (h) - sc-410841-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ITPase CRISPR Activation Plasmid (h2) - sc-410841-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ITPase Lentiviral Activation Particles (h) - sc-410841-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ITPase Lentiviral Activation Particles (h2) - sc-410841-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ITPase siRNA (h) - sc-75348 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ITPase shRNA Plasmid (h) - sc-75348-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ITPase shRNA (h) Lentiviral Particles - sc-75348-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ITPA RNAi - H00003704-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU022661 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® Human Phosphatase - SIHP0288 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0286 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0982 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0287 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

CompoZr® Knockout ZFN Kit - CKOZFN10832 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10832 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

ITPA siRNA (Human) - CRH2492 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ITPA RNAi - H00003704-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

ITPA, siRNA - MBS8209887 from MyBioSource

Category siRNA
Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ITPA (NM_181493.2) - SHH321613 from Creative biogene

Category siRNA
Species Reactivities Human

ITPA shRNA Plasmid (Human) - CHH2492 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ITPA miRNA 3'UTR clone - MiUTR3H-01209 from Creative biogene

Species Reactivities Human
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