CD79A

Gene Symbol CD79A
Entrez Gene 973
Alt Symbol IGA, MB-1
Species Human
Gene Type protein-coding
Description CD79a molecule, immunoglobulin-associated alpha
Other Description B-cell antigen receptor complex-associated protein alpha chain|CD79a antigen (immunoglobulin-associated alpha)|MB-1 membrane glycoprotein|ig-alpha|membrane-bound immunoglobulin-associated protein|surface IgM-associated protein
Swissprots A0N775 Q53FB8 P11912
Accessions AAA20495 AAA57274 CCF76935 CCF76936 EAW57075 EAW57076 P11912 AF283770 AAG15590 AK223371 BAD97091 AK315337 BAG37737 BC018964 BC113731 AAI13732 BC113733 AAI13734 HQ258131 ADR82885 M74721 AAA60270 M80462 AAA59556 M86921 AAA59557 S46706 AAB23558 S75217 AAB20812 S79248 AAC60653 X13451 CAA31802 X83540 CAA58523 NM_001783 NP_001774 NM_021601 NP_067612
Function Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src- family tyrosine kinases. Represses BCR signaling during development of immature B-cells. {ECO:0000269|PubMed:8617796, ECO:0000269|PubMed:9057631}.
Subcellular Location Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts. {ECO:0000250}.
Tissue Specificity B-cells.
Top Pathways B cell receptor signaling pathway, Primary immunodeficiency

Phospho-CD79A (Tyr182) Antibody - 5173 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Ramos cells untreated or treated with anti-human IgM (12 µg/ml for 10 minutes), using Phospho-CD79A (Tyr182) Antibody (upper) or CD79A Antibody #3351 (lower).

CD79A (D1X5C) XP ® Rabbit mAb - 13333 from Cell Signaling Technology

Prices $277.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D1X5C
Western blot analysis of extracts from various cell lines using CD79A (D1X5C) XP ® Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

CD79A Antibody - 3351 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Raji and Daudi cell lines using CD79A Antibody.

CD79A (A-3) - sc-390372 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD79A (A-3): sc-390372. Western blot analysis of CD79A expression in GA-10 (A), Ramos (B) and Raji (C) whole cell lysates.

CD79A (HM47) - sc-20064 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD79A (HM47) PE: sc-20064 PE. Intracellular FCM analysis of fixed and permeabilized GA-10 cells. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-2866.

CD79A (H-116) - sc-25604 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

CD79A (HM57) - sc-53208 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD79A (HM57): sc-53208. Western blot analysis of CD79A expression in Daudi (A), GA-10 (B) and Ramos (C) whole cell lysates.

CD79A (JCB117) - sc-53209 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
goat anti-rat IgG-CFL 405: sc-362253. Immunofluorescence staining of formalin-fixed HepG2 cells showing cytoskeletal localization. Antibody tested: α Tubulin (YL1/2): sc-53029. Goat anti-rat IgG was conjugated to CruzFluor™ 405 succinimidyl ester: sc-362616.

CD79A (C-20) - sc-8502 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CD79A (ZL7-4) - sc-13529 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD79A (ZL7-4) FITC: sc-13529 FITC. FCM analysis of human peripheral blood leukocytes. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-2855.

Anti-CD79a antibody - ab5691 from Abcam

Prices $379.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human tonsil stained with ab5691.

Anti-CD79a antibody - ab4056 from Abcam

Prices $372.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal

Anti-CD79a antibody - ab74460 from Abcam

Prices $376.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
ab74460, at 1/200 dilution, staining CD79a in human tonsil by Immunohistochemistry using formalin-fixed, paraffin-embedded tissue.

Anti-CD79a antibody - ab88525 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-CD79a antibody (ab88525) at 1 µg/ml + Spleen (Human) Tissue Lysate - adult normal tissue (ab29699) at 10 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-CD79a antibody [11D10] - ab49647 from Abcam

Host Mouse
Clonality Monoclonal
Clone 11D10

Anti-CD79a antibody [EP3618] - ab79414 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP3618
All lanes : Anti-CD79a antibody [EP3618] (ab79414) at 1/10000 dilutionLane 1 : Raji cell lysateLane 2 : Daudi cell lysateLane 3 : Human tonsil tissue lysateLane 4 : Human spleen tissue lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-CD79a antibody [EPR3619] - ab133483 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3619
All lanes : Anti-CD79a antibody [EPR3619] (ab133483) at 1/1000 dilutionLane 1 : Raji cell lysateLane 2 : Ramos cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-CD79a antibody [HM47] (Phycoerythrin) - ab177274 from Abcam

Prices $185.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone HM47

Anti-CD79a antibody [HM47], prediluted (PerCP/Cy5.5®) - ab155344 from Abcam

Prices $376.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone HM47
Flow cytometric analysis of normal Human peripheral blood cells with Anti-Human CD19 FITC followed by intracellular staining with Mouse IgG1 K Isotype Control PerCP-Cy5.5 (left) or ab155344 (right) using IC Fixation and Permeabilization Buffers. Cells in the lymphocyte gate were used for analysis.

Anti-CD79a antibody [HM47] - C-terminal - ab176509 from Abcam

Host Mouse
Clonality Monoclonal
Clone HM47

Anti-CD79a antibody [HM47] - C-terminal, prediluted (Allophycocyanin) - ab188420 from Abcam

Prices $370.00
Sizes 100 tests
Host Mouse
Clonality Monoclonal
Clone HM47

Anti-CD79a antibody [HM47/A9] - ab3121 from Abcam

Prices $400.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone HM47/A9
Human peripheral blood lymphocytes stained with ab3121 (red line). Human whole blood was processed using a modified protocol based on Chow et al, 2005 (PMID: 16080188). In brief, human whole blood was fixed in 4% formaldehyde (methanol-free) for 10 min at 22°C. Red blood cells were then lyzed by the addition of Triton X-100 (final concentration - 0.1%) for 15 min at 37°C. For experimentation, cells were treated with 50% methanol (-20°C) for 15 min at 4°C. Cells were then incubated with the antibody (ab3121, 0.01μg/1x106 cells) for 30 min at 4°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 4°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >30,000 total events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. Gating strategy - peripheral

Anti-CD79a antibody [HM47/A9] (Biotin) - ab79437 from Abcam

Prices $372.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
Clone HM47/A9

Anti-CD79a antibody [HM47/A9], prediluted - ab74591 from Abcam

Prices $370.00
Sizes 7 ml
Host Mouse
Clonality Monoclonal
Clone HM47/A9

Anti-CD79a antibody [HM47/A9], prediluted - ab7491 from Abcam

Prices $370.00
Sizes 6 ml
Host Mouse
Clonality Monoclonal
Clone HM47/A9
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