CD79A

Gene Symbol	CD79A
Entrez Gene	973
Alt Symbol	IGA, MB-1
Species	Human
Gene Type	protein-coding
Description	CD79a molecule, immunoglobulin-associated alpha
Other Description	B-cell antigen receptor complex-associated protein alpha chain|CD79a antigen (immunoglobulin-associated alpha)|MB-1 membrane glycoprotein|ig-alpha|membrane-bound immunoglobulin-associated protein|surface IgM-associated protein
Swissprots	A0N775 Q53FB8 P11912
Accessions	AAA20495 AAA57274 CCF76935 CCF76936 EAW57075 EAW57076 P11912 AF283770 AAG15590 AK223371 BAD97091 AK315337 BAG37737 BC018964 BC113731 AAI13732 BC113733 AAI13734 HQ258131 ADR82885 M74721 AAA60270 M80462 AAA59556 M86921 AAA59557 S46706 AAB23558 S75217 AAB20812 S79248 AAC60653 X13451 CAA31802 X83540 CAA58523 NM_001783 NP_001774 NM_021601 NP_067612
Function	Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src- family tyrosine kinases. Represses BCR signaling during development of immature B-cells. {ECO:0000269|PubMed:8617796, ECO:0000269|PubMed:9057631}.
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts. {ECO:0000250}.
Tissue Specificity	B-cells.
Top Pathways	B cell receptor signaling pathway, Primary immunodeficiency

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CD79a full length protein - ab170086 from Abcam Category Protein Prices $1,131.00 Sizes 5 mg Source Native Species Human

Human CD79a peptide - ab101383 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human CD79a protein fragment - ab112267 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human IgA full length protein - ab91025 from Abcam Category Protein Source Native Species Human

CD79A Antibody Blocking Peptide - LS-E2153 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CD79A Antibody Blocking Peptide - LS-E3729 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CD79A Antibody Blocking Peptide - LS-E23059 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CD79A Partial Recombinant Protein - H00000973-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Human IgA Full length Protein - NBP1-97039 from Novus Biologicals Category Protein Prices $199.00 Sizes 1 mg Species Human

CD79A Recombinant Protein - H00000973-G01 from Novus Biologicals Category Protein Prices $579.00 Sizes 10 µg Species Human

CD79A-Antibody-C-term-Blocking-peptide - BP13059b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CD79A-Antibody-Center-Blocking-Peptide - BP14939c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human IgA protein - orb107940 from Biorbyt Category Protein Prices $247.00 Sizes 1 mg Source Sample obtained from Human Plasma. Species Human

Human Secretory IgA - orb22122 from Biorbyt Category Protein Prices $553.00 Sizes 500 µg Source Human colostrum Species Human

Human Iga Protein - abx067172 from Abbexa Category Protein Source E.coli Species Human

Human IgA Protein - abx060991 from Abbexa Category Protein Source Human Plasma

CD79a - H00000973-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

CD79a - H00000973-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CD79a - H00000973-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Human IgA - AR00086PU-N from Acris Antibodies Category Protein Prices $205.00 Sizes 1 mg Source Plasma Species Human

Human IgA (secretory) - AR05238PU-N from Acris Antibodies Category Protein Prices $400.00 Sizes 500 µg Source Human Species Human

Human IgA (secretory) - BA325 from Acris Antibodies Category Protein Prices $540.00 Sizes 5 mg Source Milk Species Human

Human IgA - P143-0 from Acris Antibodies Category Protein Prices $205.00 Sizes 1 mg Source Serum Species Human

Human IgA - P143-3 from Acris Antibodies Category Protein Prices $350.00 Sizes 10 mg Source Serum Species Human

Human IgA - P143-9 from Acris Antibodies Category Protein Prices $205.00 Sizes 10 mg Source Plasma Species Human

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