LPCAT3
| Gene Symbol | LPCAT3 |
|---|---|
| Entrez Gene | 10162 |
| Alt Symbol | C3F, LPCAT, LPLAT 5, LPSAT, MBOAT5, OACT5, nessy |
| Species | Human |
| Gene Type | protein-coding |
| Description | lysophosphatidylcholine acyltransferase 3 |
| Other Description | 1-acylglycerophosphocholine O-acyltransferase|1-acylglycerophosphoserine O-acyltransferase|O-acyltransferase (membrane bound) domain containing 5|O-acyltransferase domain-containing protein 5|lyso-PC acyltransferase 3|lyso-PS acyltransferase|lysophosphatidylserine acyltransferase|lysophospholipid acyltransferase 5|membrane bound O-acyltransferase domain containing 5|membrane-bound O-acyltransferase domain-containing protein 5|putative protein similar to nessy |
| Swissprots | B7Z3N3 Q6P1A2 Q92980 Q9BW40 B2RDH0 Q7KZS1 |
| Accessions | AAB51326 EAW88691 EAW88692 EAW88693 Q6P1A2 AK058063 AK096775 AK296145 BAH12269 AK296164 BAH12270 AK296171 BAH12271 AK311727 AK315538 BAG37917 AM393271 CAL38149 AU125262 BC000664 AAH00664 BC065194 AAH65194 BT007000 AAP35646 BX647983 BX648009 U72515 AAC51640 U72517 NM_005768 NP_005759 |
| Function | Acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3- phosphocholine or PC) (LPCAT activity). Catalyzes also the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero- 3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl-sn- glycero-3-phospho-L-serine or PS) (LPSAT activity). Has also weak lysophosphatidylethanolamine acyltransferase activity (LPEAT activity). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs. Seems to be the major enzyme contributing to LPCAT activity in the liver. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. {ECO:0000269|PubMed:18195019, ECO:0000269|PubMed:18772128}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:18195019}; Multi-pass membrane protein {ECO:0000269|PubMed:18195019}. |
| Tissue Specificity | Highly expressed in liver, pancreas and adipose tissue. Very low expression in skeletal muscle and heart. Detected in neutrophils. {ECO:0000269|PubMed:18195019, ECO:0000269|PubMed:18772128}. |
| Top Pathways | Glycerophospholipid metabolism |
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