LPCAT3

Gene Symbol LPCAT3
Entrez Gene 10162
Alt Symbol C3F, LPCAT, LPLAT 5, LPSAT, MBOAT5, OACT5, nessy
Species Human
Gene Type protein-coding
Description lysophosphatidylcholine acyltransferase 3
Other Description 1-acylglycerophosphocholine O-acyltransferase|1-acylglycerophosphoserine O-acyltransferase|O-acyltransferase (membrane bound) domain containing 5|O-acyltransferase domain-containing protein 5|lyso-PC acyltransferase 3|lyso-PS acyltransferase|lysophosphatidylserine acyltransferase|lysophospholipid acyltransferase 5|membrane bound O-acyltransferase domain containing 5|membrane-bound O-acyltransferase domain-containing protein 5|putative protein similar to nessy
Swissprots B7Z3N3 Q6P1A2 Q92980 Q9BW40 B2RDH0 Q7KZS1
Accessions AAB51326 EAW88691 EAW88692 EAW88693 Q6P1A2 AK058063 AK096775 AK296145 BAH12269 AK296164 BAH12270 AK296171 BAH12271 AK311727 AK315538 BAG37917 AM393271 CAL38149 AU125262 BC000664 AAH00664 BC065194 AAH65194 BT007000 AAP35646 BX647983 BX648009 U72515 AAC51640 U72517 NM_005768 NP_005759
Function Acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3- phosphocholine or PC) (LPCAT activity). Catalyzes also the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero- 3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl-sn- glycero-3-phospho-L-serine or PS) (LPSAT activity). Has also weak lysophosphatidylethanolamine acyltransferase activity (LPEAT activity). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs. Seems to be the major enzyme contributing to LPCAT activity in the liver. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. {ECO:0000269|PubMed:18195019, ECO:0000269|PubMed:18772128}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:18195019}; Multi-pass membrane protein {ECO:0000269|PubMed:18195019}.
Tissue Specificity Highly expressed in liver, pancreas and adipose tissue. Very low expression in skeletal muscle and heart. Detected in neutrophils. {ECO:0000269|PubMed:18195019, ECO:0000269|PubMed:18772128}.
Top Pathways Glycerophospholipid metabolism

MBOAT5 CRISPR/Cas9 KO Plasmid (h) - sc-403597 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MBOAT5 HDR Plasmid (h) - sc-403597-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MBOAT5 Double Nickase Plasmid (h) - sc-403597-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MBOAT5 Double Nickase Plasmid (h2) - sc-403597-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MBOAT5 CRISPR Activation Plasmid (h) - sc-403597-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MBOAT5 CRISPR Activation Plasmid (h2) - sc-403597-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MBOAT5 Lentiviral Activation Particles (h) - sc-403597-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MBOAT5 Lentiviral Activation Particles (h2) - sc-403597-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MBOAT5 siRNA (h) - sc-95749 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MBOAT5 shRNA Plasmid (h) - sc-95749-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MBOAT5 shRNA (h) Lentiviral Particles - sc-95749-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU001051 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN12649 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12649 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

LPCAT3 siRNA (Human) - CRH6861 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human LPCAT3 (NM_005768.5) - SHH333499 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human MBOAT5(NM_005768.5) - SHH179993 from Creative biogene

Category siRNA
Species Reactivities Human

Human LPCAT3 siRNA - orb267363 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

LPCAT3 shRNA Plasmid (Human) - CHH6861 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

LPCAT3 miRNA 3'UTR clone - MiUTR1H-06141 from Creative biogene

Species Reactivities Human
Search more