| Gene Symbol | MCM3AP |
|---|---|
| Entrez Gene | 8888 |
| Alt Symbol | GANP, MAP80, SAC3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | minichromosome maintenance complex component 3 associated protein |
| Other Description | 80 kDa MCM3-associated protein|MCM3 acetylating protein|MCM3 acetyltransferase|MCM3 import protein|MCM3 minichromosome maintenance deficient 3 associated protein|germinal center-associated nuclear protein|germinal-center associated nuclear protein|germinal-centre associated nuclear protein |
| Swissprots | Q9UMT4 Q6PJP6 O60318 C9JL56 Q9BSY5 Q2M3C1 |
| Accessions | AAS89300 CCQ43242 EAX09296 O60318 AA659734 AB005543 BAA25170 AB011144 BAA25498 AJ010089 CAB52687 AK022303 AK026578 AK095181 BAG53000 AK126313 BAG54306 AK127239 BAG54460 AK304208 BAH14134 AL079407 BC004497 AAH04497 BC013285 AAH13285 BC104958 AAI04959 BC104960 AAI04961 HF584748 CCQ44045 XM_005261203 XP_005261260 XM_005261204 XP_005261261 XM_005261205 XP_005261262 XM_005261206 XP_005261263 XM_006724064 XP_006724127 XR_937577 NM_003906 NP_003897 |
| Function | Isoform GANP: Essential for the generation of high- affinity B-cells against T-cell-dependent antigens by affecting somatic hypermutation at the IgV-regions. May have stimulation- dependent DNA primase activity that would generate extra RNA primers in very rapidely proliferating cells and would support clonal expansion of differentiating B-cells (By similarity). Involved in the nuclear export of poly(A)-containing mRNAs by acting as a scaffold for the TREX-2 complex. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. {ECO:0000250, ECO:0000269|PubMed:22307388}. |
| Subcellular Location | Isoform GANP: Cytoplasm. Nucleus envelope. Nucleus, nuclear pore complex. Note=In B-cells nuclear import depends on interaction with AICDA/AID, and GANP is selectively targeted to the IgV-region gene. {ECO:0000250}. |
MCM3AP CRISPR/Cas9 KO Plasmid (h) - sc-406369 from Santa Cruz Biotechnology
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MCM3AP HDR Plasmid (h) - sc-406369-HDR from Santa Cruz Biotechnology
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MCM3AP Double Nickase Plasmid (h) - sc-406369-NIC from Santa Cruz Biotechnology
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MCM3AP Double Nickase Plasmid (h2) - sc-406369-NIC-2 from Santa Cruz Biotechnology
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MCM3AP CRISPR Activation Plasmid (h) - sc-406369-ACT from Santa Cruz Biotechnology
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MCM3AP CRISPR Activation Plasmid (h2) - sc-406369-ACT-2 from Santa Cruz Biotechnology
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MCM3AP Lentiviral Activation Particles (h) - sc-406369-LAC from Santa Cruz Biotechnology
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MCM3AP Lentiviral Activation Particles (h2) - sc-406369-LAC-2 from Santa Cruz Biotechnology
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MCM3AP siRNA (h) - sc-91405 from Santa Cruz Biotechnology
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MCM3AP shRNA Plasmid (h) - sc-91405-SH from Santa Cruz Biotechnology
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MCM3AP shRNA (h) Lentiviral Particles - sc-91405-V from Santa Cruz Biotechnology
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MCM3AP RNAi - H00008888-R01 from Novus Biologicals
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MISSION® esiRNA - EHU092491 from Sigma-Aldrich
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MISSION® esiRNA - EHU000171 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13119 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13119 from Sigma-Aldrich
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MCM3AP siRNA (Human) - CRH5874 from Cohesion Biosciences
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MCM3AP CRISPR/Cas9 KO Plasmid (h2) - sc-406369-KO-2 from Santa Cruz Biotechnology
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MCM3AP HDR Plasmid (h2) - sc-406369-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human MCM3AP (NM_003906.3) - SHH339299 from Creative biogene
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shRNA set against Human MCM3AP(NM_003906.3) - SHH181343 from Creative biogene
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MCM3AP shRNA Plasmid (Human) - CHH5874 from Cohesion Biosciences
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MCM3AP miRNA 3'UTR clone - MiUTR1H-06163 from Creative biogene
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