Gene Symbol | S1PR2 |
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Entrez Gene | 9294 |
Alt Symbol | AGR16, EDG-5, EDG5, Gpcr13, H218, LPB2, S1P2 |
Species | Human |
Gene Type | protein-coding |
Description | sphingosine-1-phosphate receptor 2 |
Other Description | S1P receptor 2|S1P receptor EDG5|S1P receptor Edg-5|endothelial differentiation G-protein coupled receptor 5|endothelial differentiation, sphingolipid G-protein-coupled receptor, 5|sphingosine 1-phosphate receptor 2|sphingosine 1-phosphate receptor Edg-5 |
Swissprots | Q86UN8 O95136 |
Accessions | AAP20652 EAW84081 EAW84082 O95136 AF034780 AAC98919 BC069598 AAH69598 BF513287 BG055846 HG510340 XM_011528425 XP_011526727 NM_004230 NP_004221 |
Function | Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Top Pathways | Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction |
EDG-5 CRISPR/Cas9 KO Plasmid (h) - sc-401114 from Santa Cruz Biotechnology
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EDG-5 HDR Plasmid (h) - sc-401114-HDR from Santa Cruz Biotechnology
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EDG-5 Double Nickase Plasmid (h) - sc-401114-NIC from Santa Cruz Biotechnology
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EDG-5 Double Nickase Plasmid (h2) - sc-401114-NIC-2 from Santa Cruz Biotechnology
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EDG-5 CRISPR Activation Plasmid (h) - sc-401114-ACT from Santa Cruz Biotechnology
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EDG-5 CRISPR Activation Plasmid (h2) - sc-401114-ACT-2 from Santa Cruz Biotechnology
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EDG-5 Lentiviral Activation Particles (h) - sc-401114-LAC from Santa Cruz Biotechnology
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EDG-5 Lentiviral Activation Particles (h2) - sc-401114-LAC-2 from Santa Cruz Biotechnology
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EDG-5 siRNA (h) - sc-39928 from Santa Cruz Biotechnology
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EDG-5 shRNA Plasmid (h) - sc-39928-SH from Santa Cruz Biotechnology
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EDG-5 shRNA (h) Lentiviral Particles - sc-39928-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN18802 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18802 from Sigma-Aldrich
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S1PR2 siRNA (Human) - CRH6152 from Cohesion Biosciences
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S1PR2 - MBS8235059 from MyBioSource
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S1P2/EDG-5/S1PR2 RNAi - H00009294-R02 from Novus Biologicals
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shRNA set against Human S1PR2 (NM_004230.3) - SHH401336 from Creative biogene
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shRNA set against Human EDG5(NM_004230.3) - SHH023861 from Creative biogene
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S1PR2 shRNA Plasmid (Human) - CHH6152 from Cohesion Biosciences
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S1PR2 miRNA 3'UTR clone - MiUTR1H-03107 from Creative biogene
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