| Gene Symbol |
SLC17A6
|
| Entrez Gene |
57084
|
| Alt Symbol |
DNPI, VGLUT2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 17 (vesicular glutamate transporter), member 6
|
| Other Description |
differentiation-associated BNPI|differentiation-associated Na(+)-dependent inorganic phosphate cotransporter|differentiation-associated Na-dependent inorganic phosphate cotransporter|solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6|solute carrier family 17 member 6|vesicular glutamate transporter 2
|
| Swissprots |
Q9P2U8 A6NKS2
|
| Accessions |
CCO13815 CCQ43632 EAW68324 Q9P2U8 AB032435 BAA92874 AK294502 BAG57719 AK309131 BC069629 AAH69629 BC069640 AAH69640 BC069646 AAH69646 BQ185289 BQ188116 CK823303 DA392769 NM_020346 NP_065079
|
| Function |
Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. {ECO:0000269|PubMed:10820226, ECO:0000269|PubMed:11698620}.
|
| Subcellular Location |
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell junction, synapse, synaptosome {ECO:0000250}.
|
| Tissue Specificity |
Predominantly expressed in adult brain. Expressed in amygdala, caudate nucleus, cerebral cortex, frontal lobe, hippocampus, medulla, occipital lobe, putamen, spinal cord, substantia nigra, subthalamic nucleus, temporal lobe and thalamus. {ECO:0000269|PubMed:10820226}.
|
| Top Pathways |
Synaptic vesicle cycle, Glutamatergic synapse, Nicotine addiction, Retrograde endocannabinoid signaling
|