Gene Symbol | SLC17A6 |
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Entrez Gene | 57084 |
Alt Symbol | DNPI, VGLUT2 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 17 (vesicular glutamate transporter), member 6 |
Other Description | differentiation-associated BNPI|differentiation-associated Na(+)-dependent inorganic phosphate cotransporter|differentiation-associated Na-dependent inorganic phosphate cotransporter|solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6|solute carrier family 17 member 6|vesicular glutamate transporter 2 |
Swissprots | Q9P2U8 A6NKS2 |
Accessions | CCO13815 CCQ43632 EAW68324 Q9P2U8 AB032435 BAA92874 AK294502 BAG57719 AK309131 BC069629 AAH69629 BC069640 AAH69640 BC069646 AAH69646 BQ185289 BQ188116 CK823303 DA392769 NM_020346 NP_065079 |
Function | Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. {ECO:0000269|PubMed:10820226, ECO:0000269|PubMed:11698620}. |
Subcellular Location | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell junction, synapse, synaptosome {ECO:0000250}. |
Tissue Specificity | Predominantly expressed in adult brain. Expressed in amygdala, caudate nucleus, cerebral cortex, frontal lobe, hippocampus, medulla, occipital lobe, putamen, spinal cord, substantia nigra, subthalamic nucleus, temporal lobe and thalamus. {ECO:0000269|PubMed:10820226}. |
Top Pathways | Synaptic vesicle cycle, Glutamatergic synapse, Nicotine addiction, Retrograde endocannabinoid signaling |
VGLUT2 CRISPR/Cas9 KO Plasmid (h) - sc-403888 from Santa Cruz Biotechnology
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VGLUT2 HDR Plasmid (h) - sc-403888-HDR from Santa Cruz Biotechnology
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VGLUT2 Double Nickase Plasmid (h) - sc-403888-NIC from Santa Cruz Biotechnology
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VGLUT2 Double Nickase Plasmid (h2) - sc-403888-NIC-2 from Santa Cruz Biotechnology
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VGLUT2 CRISPR Activation Plasmid (h) - sc-403888-ACT from Santa Cruz Biotechnology
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VGLUT2 CRISPR Activation Plasmid (h2) - sc-403888-ACT-2 from Santa Cruz Biotechnology
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VGLUT2 Lentiviral Activation Particles (h) - sc-403888-LAC from Santa Cruz Biotechnology
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VGLUT2 Lentiviral Activation Particles (h2) - sc-403888-LAC-2 from Santa Cruz Biotechnology
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VGLUT2 siRNA (h) - sc-42332 from Santa Cruz Biotechnology
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VGLUT2 shRNA Plasmid (h) - sc-42332-SH from Santa Cruz Biotechnology
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VGLUT2 shRNA (h) Lentiviral Particles - sc-42332-V from Santa Cruz Biotechnology
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VGLUT2 RNAi - H00057084-R01 from Novus Biologicals
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MISSION® esiRNA - EHU084361 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19438 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19438 from Sigma-Aldrich
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SLC17A6 siRNA (Human) - CRJ1309 from Cohesion Biosciences
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SLC17A6 - MBS8209955 from MyBioSource
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Human SLC17A6 siRNA - orb271810 from Biorbyt
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SLC17A6 shRNA Plasmid (Human) - CHJ1309 from Cohesion Biosciences
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SLC17A6 miRNA 3'UTR clone - MiUTR3H-09311 from Creative biogene
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