| Gene Symbol |
ENTPD8
|
| Entrez Gene |
377841
|
| Alt Symbol |
E-NTPDase, GLSR2492, NTPDase-8, UNQ2492
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ectonucleoside triphosphate diphosphohydrolase 8
|
| Other Description |
E-NTPDase 8|liver ecto-ATP-diphosphohydrolase
|
| Swissprots |
A2BG17 Q6UVZ0 Q5MY95
|
| Accessions |
EAW88389 Q5MY95 AY359088 AAQ89446 AY430414 AAR04374 AY903953 AAW83515 AY903954 AAW83516 BC050293 BC140368 AAI40369 BC141810 AAI41811 BC146509 AAI46510 XM_011518665 XP_011516967 XM_011518666 XP_011516968 XM_011518667 XP_011516969 XM_011518668 XP_011516970 NM_001033113 NP_001028285 NM_198585 NP_940987
|
| Function |
Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP. {ECO:0000269|PubMed:16752921, ECO:0000269|PubMed:17095758}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
| Top Pathways |
Epstein-Barr virus infection, Purine metabolism, Pyrimidine metabolism
|