Gene Symbol | ENTPD8 |
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Entrez Gene | 377841 |
Alt Symbol | E-NTPDase, GLSR2492, NTPDase-8, UNQ2492 |
Species | Human |
Gene Type | protein-coding |
Description | ectonucleoside triphosphate diphosphohydrolase 8 |
Other Description | E-NTPDase 8|liver ecto-ATP-diphosphohydrolase |
Swissprots | A2BG17 Q6UVZ0 Q5MY95 |
Accessions | EAW88389 Q5MY95 AY359088 AAQ89446 AY430414 AAR04374 AY903953 AAW83515 AY903954 AAW83516 BC050293 BC140368 AAI40369 BC141810 AAI41811 BC146509 AAI46510 XM_011518665 XP_011516967 XM_011518666 XP_011516968 XM_011518667 XP_011516969 XM_011518668 XP_011516970 NM_001033113 NP_001028285 NM_198585 NP_940987 |
Function | Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP. {ECO:0000269|PubMed:16752921, ECO:0000269|PubMed:17095758}. |
Subcellular Location | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
Top Pathways | Epstein-Barr virus infection, Purine metabolism, Pyrimidine metabolism |
NTPDase8 CRISPR/Cas9 KO Plasmid (h) - sc-410664 from Santa Cruz Biotechnology
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NTPDase8 HDR Plasmid (h) - sc-410664-HDR from Santa Cruz Biotechnology
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NTPDase8 Double Nickase Plasmid (h) - sc-410664-NIC from Santa Cruz Biotechnology
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NTPDase8 Double Nickase Plasmid (h2) - sc-410664-NIC-2 from Santa Cruz Biotechnology
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NTPDase8 CRISPR Activation Plasmid (h) - sc-410664-ACT from Santa Cruz Biotechnology
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NTPDase8 CRISPR Activation Plasmid (h2) - sc-410664-ACT-2 from Santa Cruz Biotechnology
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NTPDase8 Lentiviral Activation Particles (h) - sc-410664-LAC from Santa Cruz Biotechnology
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NTPDase8 Lentiviral Activation Particles (h2) - sc-410664-LAC-2 from Santa Cruz Biotechnology
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NTPDase8 siRNA (h) - sc-92553 from Santa Cruz Biotechnology
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NTPDase8 shRNA Plasmid (h) - sc-92553-SH from Santa Cruz Biotechnology
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NTPDase8 shRNA (h) Lentiviral Particles - sc-92553-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU036331 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0202 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0956 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0204 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0957 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0203 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7896 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7896 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03931 from Sigma-Aldrich
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ENTPD8 siRNA (Human) - CRJ7696 from Cohesion Biosciences
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ENTPD8 - MBS8201598 from MyBioSource
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shRNA set against Human ENTPD8 (NM_198585.2) - SHH286109 from Creative biogene
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shRNA set against Human ENTPD8(NM_198585.2) - SHH034957 from Creative biogene
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shRNA set against Human ENTPD8(NM_001033113.1) - SHH034985 from Creative biogene
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