| Gene Symbol |
Lipe
|
| Entrez Gene |
16890
|
| Alt Symbol |
4933403G17Rik, HSL
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
lipase, hormone sensitive
|
| Other Description |
hormone-sensitive lipase
|
| Swissprots |
Q3TE34 P97866 P54310 Q8CDI9 Q6GU16
|
| Accessions |
AAA50232 AAC53069 AAP84985 EDL24271 EDL24272 P54310 AK016633 BAB30349 AK019846 BAB31878 AK029984 BAC26716 AK169858 BAE41414 BC021642 AAH21642 BC053502 BY513432 U08188 AAC52163 XM_006539570 XP_006539633 XM_006539571 XP_006539634 XM_006539572 XP_006539635 NM_001039507 NP_001034596 NM_010719 NP_034849
|
| Function |
In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. {ECO:0000269|PubMed:23291629}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}. Membrane, caveola {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation. {ECO:0000250}.
|
| Top Pathways |
Insulin signaling pathway, AMPK signaling pathway, cAMP signaling pathway
|