| Gene Symbol | EWSR1 |
|---|---|
| Entrez Gene | 2130 |
| Alt Symbol | EWS, bK984G1.4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | EWS RNA-binding protein 1 |
| Other Description | EWS RNA-binding protein variant 6|Ewing sarcoma breakpoint region 1|Ewings sarcoma EWS-Fli1 (type 1) oncogene|RNA-binding protein EWS |
| Swissprots | Q96FE8 Q96MN4 Q01844 Q96MX4 Q92635 B0QYK1 Q9BWA2 Q5THL0 |
| Accessions | AAD15010 BAA31990 CAA51489 CAA69177 CAA70044 CAH33891 EAW59780 EAW59781 EAW59782 EAW59783 EAW59784 EAW59785 EAW59786 EAW59787 Q01844 AI564543 AK026270 AK056309 BAB71145 AK056681 BAB71252 AK096787 AK127624 AK225096 AK225102 AL833489 AW205707 BC000527 AAH00527 BC004817 AAH04817 BC011048 AAH11048 BC072442 AAH72442 BE741903 BM981230 BX648769 CR456490 CAG30376 CU013087 CAK54518 CU013375 CAK54817 CX786322 DA013931 DA051447 DB051511 DB443651 EU327511 ABY40719 JX977847 AGS36504 S62665 AAB27172 X66899 CAA47350 XM_005261389 XP_005261446 XM_005261390 XP_005261447 XM_011529995 XP_011528297 XM_011529996 XP_011528298 XM_011529997 XP_011528299 XM_011529998 XP_011528300 XM_011529999 XP_011528301 XM_011530000 XP_011528302 XM_011530001 XP_011528303 XM_011530002 XP_011528304 NM_001163285 NP_001156757 NM_001163286 NP_001156758 NM_001163287 NP_001156759 NM_005243 NP_005234 NM_013986 NP_053733 |
| Function | Might normally function as a transcriptionnal repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:16965792}. Cytoplasm {ECO:0000269|PubMed:16965792}. Cell membrane {ECO:0000269|PubMed:16965792}. Note=Relocates from cytoplasm to ribosomes upon PTK2B/FAK2 activation. |
| Tissue Specificity | Ubiquitous. |
| Top Pathways | Transcriptional misregulation in cancer |
Human-EWSR1-cDNA-Clone - DC00251 from Abgent, a WuXi AppTec company
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Human EWSR1 cDNA clone(NM_001163285.1) - CDFH006180 from Creative Biomart
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Human EWSR1 cDNA clone(NM_001163286.1) - CDFH006181 from Creative Biomart
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Human EWSR1 cDNA clone(NM_001163287.1) - CDFH006182 from Creative Biomart
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Human EWSR1 cDNA clone(NM_013986.3) - CDFH006186 from Creative Biomart
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Human EWSR1 ORF Clone(NM_001163285.1) - CDCL162691 from Creative Biomart
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Human EWSR1 ORF Clone(NM_001163285.1) - CDCL162692 from Creative Biomart
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Human EWSR1 ORF Clone(NM_013986.3) - CDCR296704 from Creative Biomart
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Human EWSR1 ORF Clone(NM_013986.3) - CDCR296706 from Creative Biomart
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Human EWSR1 ORF Clone(NM_001163285.1) - CDCR354350 from Creative Biomart
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Human EWSR1 ORF Clone(NM_001163285.1) - CDCR354351 from Creative Biomart
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Human EWSR1 ORF Clone(NM_001163286.1) - CDCR354353 from Creative Biomart
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Human EWSR1 ORF Clone(NM_001163287.1) - CDCR354354 from Creative Biomart
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Human EWSR1 ORF Clone(NM_001163287.1) - CDCR354355 from Creative Biomart
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Human EWSR1 ORF Clone(NM_001163286.1) - CDCR354358 from Creative Biomart
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Human EWSR1 ORF Clone(NM_013986.3) - CDCR296704 from Creative biogene
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Human EWSR1 ORF Clone(NM_001163287.1) - CDCR354354 from Creative biogene
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Human EWSR1 ORF clone (NM_001163285.1) - CDCR061746 from Creative biogene
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Human EWSR1 ORF clone (NM_001163286.1) - CDCR061748 from Creative biogene
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Human EWSR1 ORF Clone (BC000527) - CDCS408716 from Creative biogene
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Human EWSR1 ORF Clone (BC004817) - CDCS408717 from Creative biogene
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Human EWSR1 ORF Clone (BC011048) - CDCS408718 from Creative biogene
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Human EWSR1 ORF Clone (BC072442) - CDCS408719 from Creative biogene
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Human EWSR1 cDNA Clone(NM_001163285.1) - CDFH006180 from Creative biogene
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Human EWSR1 cDNA Clone(NM_001163286.1) - CDFH006181 from Creative biogene
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